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CAS No.: 107316-88-1

Demethylzeylasteral/去甲泽拉木醛 Catalog No. CSN15657

Synonyms: ZST93;T-96;TZ-93

Demethylzeylasteral, a natural product isolated and purified from the herb of Tripterygium wilfordii Hook.f., has strong immunosuppressive activity, that can be used in the fields of organ transplantation and autoimmune disorders. It increases both activation and inactivation time constants of Ca(2+) currents, and inhibits significantly the sperm acrosome reaction initiated by progesterone.

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技术信息

生物活性

描述Demethylzeylasteral (T-96) is a triterpene compound isolated from Tripterygium wilfordii Hook F, with anti-inflammatory, immunosuppressive and anti-tumor activities. T-96 inhibited TGF-β-induced migration and epithelial-mesenchymal transition both in vitro and in vivo. T-96 inhibited invasion of MDA-MB-231 and 4T1 cells via suppressing the canonical and non-canonical TGF-β signaling pathways^[3]. T-96 significantly inhibited glioma cell growth and induced cell cycle arrest in G1 phase but did not induce apoptosis. Cell invasion and migration were dramatically suppressed after treatment with T-96^[4]. Compared with the rats in the unilateral ureteral obstruction model group, demethylzeylasteral treatment markedly inhibited the increased concentrations of serum creatinine and blood urea nitrogen, urinary protein/creatinine ratio, and concentrations of high‑density lipoprotein and low‑density lipoprotein cholesterol, and prevented kidney damage. In addition, demethylzeylasteral inhibited the levels of TNF‑α andIL‑6 and suppressed the protein expression levels of COX‑2 (cyclooxygenase) and ICAM‑1 (intercellular adhesion molecule‑1) in the kidneys of the rats in the unilateral ureteral obstruction model. Demethylzeylasteral also significantly suppressed the protein expression of NF‑κB p65^[5]. Demethylzeylasteral not only inhibits cell proliferation through cell cycle arrest at S phase, but also induces cell apoptosis in melanoma cells^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0808 mL
- 10.4039 mL
- 20.8078 mL
- 5 mM
- 0.4162 mL
- 2.0808 mL
- 4.1616 mL
- 10 mM
- 0.2081 mL
- 1.0404 mL
- 2.0808 mL

技术信息

CAS号

107316-88-1

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C29H36O6

运输

蓝冰

分子量

480.59

别名

ZST93;T-96;TZ-93;去甲泽拉木醛

溶解度

DMSO	96.0 mg/mL (199.8 mM)
Water	Insoluble
Ethanol	32.0 mg/mL (66.6 mM)

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Demethylzeylasteral/去甲泽拉木醛 Catalog No. CSN15657

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