|(R)-3-(3-氟-4-(1-甲基-5,6-二氢-1,2,4-三嗪-4(1H)-基)苯基)-5-(羟甲基)恶唑烷-2-酮|CsnPharm

CAS No.: 1219707-39-7

Synonyms: LCB01-0371

LCB01-0371 shows good activity against Gram-positive pathogens.

规格	价格	促销价格	库存	数量

400-920-2911

加入购物车大规格询价

产品咨询

400-920-2911

纯度 & 质量文件批次:

生物活性

描述LCB01-0371 is a new oxazolidinone with cyclic amidrazone. In vitro activity of LCB01-0371 against 624 clinical isolates was evaluated and compared with those of linezolid, vancomycin, and other antibiotics. LCB01-0371 shows good activity against Gram-positive pathogens. LCB01-0371 is more active than linezolid against these systemic infections. LCB01-0371 shows bacteriostatic activity against Staphylococcus aureus^[3]. LCB01-0371 was effective against several M. abscessus strains in vitro and in a macrophage model of infection. In the murine model, a similar efficacy to linezolid was achieved, especially in the lungs. LCB01-0371 inhibited the growth of amikacin-, cefoxitin-, and clarithromycin-resistant strains^[4]. Delpazolid(LCB01-0371) exhibited better antimicrobial activity against the Mycobacterium fortuitum isolates when compared to linezolid, with 4-fold lower MIC values^[5]. LCB01-0371 is well tolerated in healthy male subjects with comparable haematology profiles to placebo, after multiple doses of up to 1200 mg twice daily for 21 days^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02836483	Pulmonary Tuberculosis	Phase 2	Recruiting	December 2018	Korea, Republic of ... more >> Asan Medical Center Recruiting Seoul, Korea, Republic of Contact: T.S. Sim, M.D., Ph.D 82-2-3010-3892 shimts@amc.seoul.kr Collapse <<
NCT01554995	Healthy	Phase 1	Completed	-	Korea, Republic of ... more >> Asan Medical Center Seoul,, Korea, Republic of, 138736 Collapse <<
NCT02540460	Healthy	Phase 1	Completed	-	Korea, Republic of ... more >> Seoul National University Bundang Hospital Bundang, Gyeonggi, Korea, Republic of Collapse <<

实验方案

技术信息

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

请登录您的专属账户