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CAS No.: 189279-58-1

Delafloxacin/德拉沙星 Catalog No. CSN16520

Synonyms: RX-3341;WQ-3034;ABT492

Delafloxacin is a fluoroquinolone antibiotic used to treat serious skin infections.

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技术信息

生物活性

描述Pneumonia is one of the most common infectious diseases encountered worldwide. The major pathogen of community-acquired pneumonia (CAP) continues to be S. pneumoniae. In the hospital setting, S. aureus and Gram-negative bacteria are more commonly encountered and are frequently drug resistant. Delafloxacin is a novel fluoroquinolone antibiotic in development for the treatment of respiratory tract infections. It has a broad spectrum of activity that includes drug-resistant S. aureus, S. pneumoniae, and Klebsiella pneumoniae. The lowest MICs were observed for S. aureus (range, 0.004 to 0.008 mg/liter). The in vitro potency against S. pneumoniae and K. pneumoniae strains was more varied (range, 0.016 to 0.125 mg/liter and 0.06 to 1 mg/liter, respectively). As for pharmacokinetics, exposure to delafloxacin increased in a dose-dependent manner across the dose range. C_max concentrations ranged from 2 to 71 mg/liter. AUC_0–∞ values ranged from 2.8 to 152 mg · h/liter and were linear across the 2.5- to 160-mg dosing range (R² of 0.99). The elimination half-life ranged from 0.7 to 1 h^[3].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01283581	Skin and Subcutaneous Tissue B... more >>acterial Infections Collapse <<	Phase 2	Completed	-	-
NCT02015637	Gonorrhea	Phase 3	Terminated	-	-
NCT01283581	-	-	Completed	-	-

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参考文献

[1] Gunderson SM, Hayes RA, Quinn JP, In vitro pharmacodynamic activities of ABT-492, a novel quinolone, compared to those of levofloxacin against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. Antimicrob Agents Chemother. 2004 Jan;48(1):203-8.
[2] Goldstein EJ, Citron DM, et al. In vitro activities of ABT-492, a new fluoroquinolone, against 155 aerobic and 171 anaerobic pathogens isolated from antral sinus puncture specimens from patients with sinusitis. Antimicrob Agents Chemother. 2003 Sep;47(9):3008-11.
[3] Lepak AJ, Andes DR. In Vivo Pharmacodynamic Target Assessment of Delafloxacin against Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumoniae in a Murine Lung Infection Model. Antimicrob Agents Chemother. 2016;60(8):4764‐4769

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.2688 mL
- 11.3440 mL
- 22.6881 mL
- 5 mM
- 0.4538 mL
- 2.2688 mL
- 4.5376 mL
- 10 mM
- 0.2269 mL
- 1.1344 mL
- 2.2688 mL

技术信息

CAS号	189279-58-1	储存条件	粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C18H12ClF3N4O4	运输	蓝冰
分子量	440.76	别名	RX-3341;WQ-3034;ABT492;Delafloxacinum;德拉沙星

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT01283581	Skin and Subcutaneous Tissue B... more >>acterial Infections Collapse <<	Phase 2	Completed	-	-
NCT02015637	Gonorrhea	Phase 3	Terminated	-	-
NCT01283581	-	-	Completed	-	-
NCT02015637	-	-	Terminated	-	-
NCT02679573	Community Acquired Bacterial P... more >>neumonia Collapse <<	Phase 3	Completed	-	-
NCT02245243	Hepatic Impairment	Phase 1	Completed	-	United States, Florida ... more >> Melinta 112 Study Site Miami, Florida, United States, 33136 Melinta 112 Study Site Orlando, Florida, United States, 32809 Collapse <<
NCT01811732	Skin and Subcutaneous Tissue B... more >>acterial Infections Collapse <<	Phase 3	Completed	-	-
NCT02505997	VA Drug Interactions	Phase 1	Completed	-	United States, Texas ... more >> PPD Development, LP Austin, Texas, United States, 78744 Collapse <<
NCT01984684	Skin and Subcutaneous Tissue B... more >>acterial Infections Skin Structures and Soft Tissue Infections Collapse <<	Phase 3	Completed	-	-
NCT01811732	-	-	Completed	-	-
NCT01984684	-	-	Completed	-	-
NCT03534622	Pneumonia	Phase 1	Completed	-	United States, Arizona ... more >> Pulmonary Associates Phoenix, Arizona, United States, 85006 Collapse <<
NCT00719810	-	-	Completed	-	-
NCT00719810	Skin Structure Infections ... more >> Bacterial Skin Diseases Staphylococcal Skin Infections Collapse <<	Phase 2	Completed	-	United States, California ... more >> Physician Alliance Research Center Anaheim, California, United States Quality of Life Medical Center, LLC Hawaiian Gardens, California, United States Tri City Medical Center Oceanside, California, United States Crest Clinical Trials Santa Ana, California, United States United States, Florida Internal Medicine Associates of Lee County Fort Myers, Florida, United States United States, Georgia Joseph M. Still Research Foundation, Inc. Augusta, Georgia, United States Southeast Regional Research Group Columbus, Georgia, United States Southeast Regional Research Group Ludowici, Georgia, United States Southeast Regional Research Group Savannah, Georgia, United States United States, Montana St. James Health Care Butte, Montana, United States United States, Ohio Riverside Methodist Hospital Columbus, Ohio, United States United States, Texas West Houston Clinical Research Services Houston, Texas, United States Westbury Medical Clinic Houston, Texas, United States Puerto Rico Clinical Research Puerto Rico, Inc San Juan, Puerto Rico Collapse <<

Delafloxacin/德拉沙星 Catalog No. CSN16520

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