|14-甲基-5-氧代-7,8-二氢-5H-吲哚并[2',3':3,4]吡啶并[2,1-b]喹唑啉-14-鎓-13-盐|CsnPharm

CAS No.: 67909-49-3

Dehydroevodiamine/去氢吴茱萸碱 Catalog No. CSN12661

Synonyms: DHED;去氢吴茱萸碱

Dehydroevodiamine is an alkaloid isolated from E. rutaecarpa and possesses anti-inflammatory, antiarrhythmic, hypotensive, and anti-amnesic biological activities.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Dehydroevodiamine (DHED) is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, and has an antiarrhythmic effect in guinea-pig ventricular myocytes^[3]. Dehydroevodiamine (0-50 μM; 2 hours) inhibits iNOS and COX-2 expression and prevents degradation of IκB-α in LPS induced RAW 264.7 macrophages^[4]. Similarly to the cholinesterase inhibitor, physostigmine (0.03--0.3 mg/kg, i.p.), dehydroevodiamine (0.75--12.0 mg/kg, i.p.) administered 30 min before the training trial, immediately after the training trial, and 30 min before the retention test significantly improved scopolamine- and beta-amyloid peptide-(25--35)-induced amnesia^[5]. DHED (10 mg/kg, p.o.) and Donepezil (1 mg/kg, p.o.) ameliorated the spatial memory impairment in the scopolamine-induced amnestic rats^[6]. DHED could suppress the overactivation of GSK-3 (glycogen synthase kinase-3) and improve tau hyperphosphorylation and spatial memory deficit of the rats^[7]. DHED (Pre-incubation of the brain slices with DHED) can attenuate CA(calyculin A)-induced tau hyperphosphorylation at multiple AD-related sites in metabolically active rat brain slices^[8].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.3185 mL
- 16.5924 mL
- 33.1849 mL
- 5 mM
- 0.6637 mL
- 3.3185 mL
- 6.6370 mL
- 10 mM
- 0.3318 mL
- 1.6592 mL
- 3.3185 mL

技术信息

CAS号

67909-49-3

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C19H15N3O

运输

蓝冰

分子量

301.34

别名

DHED;去氢吴茱萸碱

溶解度

DMSO	14.0 mg/mL (46.5 mM) warming
Water	insoluble

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Dehydroevodiamine/去氢吴茱萸碱 Catalog No. CSN12661

靶点选择性

请登录您的专属账户

确认信息