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CAS No.: 477-43-0

Dehydrocostus Lactone/去氢木香内酯 Catalog No. CSN12303

Synonyms: (-)-Dehydrocostus lactone;Epiligulyl oxide;Dehydrocostus lactone

Dehydrocostus Lactone a naturally occuring sesquiterpene lactone in the roots of Saussurea lappa with anti-inflammatory activity.

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技术信息

生物活性

描述Dehydrocostus Lactone is a major sesquiterpene lactone isolated from the roots of Saussurea lappa. Dehydrocostus Lactone a naturally occuring sesquiterpene lactone in the roots of Saussurea lappa with anti-inflammatory activity^[3]. Dehydrocostus lactone) isolated from the medicinal plant, Saussurea lappa, inhibited the production of NO in lipopolysaccharide (LPS)-activated RAW 264.7 cells by suppressing inducible nitric oxide synthase enzyme expression. This compound also decreased the TNF-alpha level in LPS-activated systems in vitro and in vivo^[4]. DHCL (Dehydrocostus Lactone) promoted apoptosis with increased activation of caspases 8, 9, 7, 3, enhanced PARP cleavage, decreased Bcl-xL expression and increased levels of Bax, Bak, Bok, Bik, Bmf, and t-Bid^[5]. DHL (Dehydrocostus Lactone) inhibited LPS-induced production of proinflammatory mediators such as iNOS, NO, and cytokines including TNF-α, IL-6, IL-1β, and IL-12 p35 by suppressing the activity of NF-κB via p38 MAPK/MK2 and Akt signaling pathway in macrophages. DHL significantly attenuated LPS-induced pathological injury and reduced cytokines expression in the lung in vivo^[6]. Dehydrocostus lactone can suppress the proliferation of K562 cells and induce the apoptosis of K562 cells through BCR/ABL-STAT signaling pathways^[7]. DHC protected against ovariectomy (OVX)-induced bone loss in mice and the protective effect was mediated at least in part through the attenuation of NF-κB signaling pathway^[8].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.3421 mL
- 21.7106 mL
- 43.4212 mL
- 5 mM
- 0.8684 mL
- 4.3421 mL
- 8.6842 mL
- 10 mM
- 0.4342 mL
- 2.1711 mL
- 4.3421 mL

技术信息

CAS号

477-43-0

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H18O2

运输

蓝冰

分子量

230.30

别名

(-)-Dehydrocostus lactone;Epiligulyl oxide;Dehydrocostus lactone;去氢木香烃内酯;去氢木香内酯

溶解度

DMSO	44.0 mg/mL (191.1 mM)
Water	Insoluble
Ethanol	45.0 mg/mL (195.4 mM)

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Dehydrocostus Lactone/去氢木香内酯 Catalog No. CSN12303

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