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CAS No.: 76822-21-4

Danshensu/丹参素 Catalog No. CSN13515

Synonyms: Dan shen suan A;Salvianic acid A;丹参素

Danshensu, a herbal preparation used in traditional Chinese medicine, possesses potential antitumor and antiangiogenesis effects.

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技术信息

生物活性

描述Danshensu, an active ingredient of Salvia miltiorrhiza, shows wide cardiovascular benefit by activating Nrf2 signaling pathway. DSS (Danshensu) significantly decreased the level of the marker enzymes (creatine kinase and lactate dehydrogenase) from the coronary effluents and myocardial infarction size. This could markedly contribute to the recovery of cardiac function after I/R (ischemia reperfusion) injury. DSS also had ROS scavenging activity and boosted endogenous antioxidants such as SOD, CAT, MDA, GSH-PX and HO-1 activities by activating nuclear factor erythroid-2-related factor 2 (Nrf2) signaling pathway which was mediated by Akt and ERK1/2 in western blot analysis^[3]. Acute treatment with a single dose of danshensu in rats with normal tHcy (plasma total homocysteine) did not change plasma tHcy. In contrast, danshensu significantly lowered tHcy in rats with elevated tHcy^[4]. Danshensu significantly decreased the right ventricle systolic pressure, the right ventricle hypertrophy and pulmonary vascular remodeling index in hypoxic pulmonary hypertension rats. Danshensu also reduced the increased expression of transforming growth factor-β and phosphorylation of smad3 in pulmonary arteries in hypoxic pulmonary hypertension rats. In vitro, danshensu inhibited the hypoxia- or transforming growth factor-β-induced proliferation of primary pulmonary artery smooth muscle cells^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.0461 mL
- 25.2305 mL
- 50.4610 mL
- 5 mM
- 1.0092 mL
- 5.0461 mL
- 10.0922 mL
- 10 mM
- 0.5046 mL
- 2.5231 mL
- 5.0461 mL

技术信息

CAS号

76822-21-4

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C9H10O5

运输

蓝冰

分子量

198.17

别名

Dan shen suan A;Salvianic acid A;丹参素

溶解度

DMSO	Insoluble
Ethanol	Insoluble

动物实验配方

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