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CAS No.: 17086-76-9

Cyasterone/杯苋甾酮 Catalog No. CSN19954

Synonyms: AI3-44890;杯苋甾酮

Cyasterone is an inhibitor of EGFR that maybe a promising anti-cancer agent espcially in skin carcinoma.

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400-920-2911

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技术信息

生物活性

描述Cyasterone, a natural EGFR inhibitor, mainly isolated from Ajuga decumbens Thunb (Labiatae). Cyasterone manifests anti-proliferation effect by induced apoptosis and cell cycle arrests. MTT assay showed that cyasterone caused a significantly decreasing of the proliferation of A549 and MGC823 cells in a time-and dose-dependent manner with IC50 values of 38.50±3.73 μg/mL on A549 cells and 32.96±1.24 μg/mL on MGC823 cells at 48h, respectively. Cyasterone treatment triggered inhibition of epidermal growth factor receptor-phosphatidylinositol 3 kinase/protein kinase B (EGFR-AKT) signaling pathways and activation of P38 pathways. Furthermore, cyasterone inhibited MGC823 cells xenografted tumor growth in vivo with few changes in body weights^[3].
参考文献

[1] Lu X, Qiu H, et al. Anti-proliferation effects, efficacy of cyasterone in vitro and in vivo and its mechanism. Biomed Pharmacother. 2016 Dec;84:330-339.
[2] Okuzumi K, Hara N, et al. Structure elucidation of cyasterone stereoisomers isolated from Cyathula officinalis. Org Biomol Chem. 2005 Apr 7;3(7):1227-32.
[3] Lu X, Qiu H, Yang L, Zhang J, Ma S, Zhen L. Anti-proliferation effects, efficacy of cyasterone in vitro and in vivo and its mechanism. Biomed Pharmacother. 2016 Dec;84:330-339

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.8634 mL
- 9.3170 mL
- 18.6340 mL
- 5 mM
- 0.3727 mL
- 1.8634 mL
- 3.7268 mL
- 10 mM
- 0.1863 mL
- 0.9317 mL
- 1.8634 mL

技术信息

CAS号

17086-76-9

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C29H44O9

运输

蓝冰

分子量

536.65

别名

AI3-44890;杯苋甾酮

溶解度

DMSO	400.0 mg/mL (745.4 mM)
Water	50.0 mg/mL (93.2 mM)

动物实验配方

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Cyasterone/杯苋甾酮 Catalog No. CSN19954

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