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CAS No.: 18444-66-1

Cucurbitacin E/葫芦素 E Catalog No. CSN10712

Synonyms: α-Elaterin;α-Elaterine;NSC 106399

Cucurbitacin E is a widely available plant-derived natural product, making it a useful tool to study actin dynamics in cells and actin-based processes such as cytokinesis.

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描述Cyclin-dependent kinases (CDKs) are a group of multifunctional enzymes consisting of catalytic and regulatory subunits^[3]. Cucurbitacin E is a natural compound which from the climbing stem of Cucumic melo L. Cucurbitacin E significantly suppresses the activity of the cyclin B1/CDC2 complex. in vitro study is initiated in which each of the CRC cell lines is exposed to increasing doses of Cucurbitacin E (0, 2.5, 5, and 7.5 μM) over a period of 24 h. Cucurbitacin E is shown to induce morphological changes in the primary colon cancer cells. A remarkable change in morphology was observed in the period of 6 and 24 h. Cucurbitacin E inhibits tumor growth by arresting the cell cycle in the G2/M phase via GADD45γ gene expression and the blockage of cyclin B1/CDC2 complex in primary CRC cells^[4]. A high fat diet mice model of metabolic syndrome (HFD-MetS) is developed to assess the role of Cucurbitacin E (CuE) on body weight and fat tissue biology. Results showed a significant decrease in body weights of mice treated with Cucurbitacin E (0.5mg/kg) and central obesity is also reduced after the treatment^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02858388	Otitis Media With Effusion	Phase 3	Completed	-	Italy ... more >> San Gennaro Hospital Naples, Italy, 80136 Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.7963 mL
- 8.9817 mL
- 17.9634 mL
- 5 mM
- 0.3593 mL
- 1.7963 mL
- 3.5927 mL
- 10 mM
- 0.1796 mL
- 0.8982 mL
- 1.7963 mL

技术信息

CAS号	18444-66-1	储存条件	粉末 Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C32H44O8	运输	蓝冰
分子量	556.69	别名	α-Elaterin;α-Elaterine;NSC 106399;NSC 521775;葫芦素 E

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