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CAS No.: 6199-67-3

Cucurbitacin B/葫芦素B Catalog No. CSN10711

Synonyms: Cuc B;NSC 49451;NSC 144154

Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and could repress cancer cell progression.

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400-920-2911

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技术信息

生物活性

描述Microtubule, a component of the cytoskeleton, plays crucial roles in various fundamental cell functions, including mitotic regulation, maintenance of cell morphology, intracellular motility and macromolecules and organelles trafficking. Cucurbitacin B, an oxygenated tetracyclic triterpenoid compound extracted from the Thai medicinal plant Trichosanthes cucumerina L., has several biological activities including anti-inflammatory, antimicrobial and anticancer through disruption of the microtubule network. It exhibited a dose-dependent inhibitory effect with the IC₅₀ of 4.12 μM and 3.68 μM for MCF-7 and MDA-MB-231 cells, respectively. In the same cell lines treated with 2.5 μM and 5 μM cucurbitacin B for 24 hr, blockage at G₂/M and apoptotic induction were observed in cucurbitacin B-treated cells. Further, cucurbitacin B treatment for 24 hr significantly induced apoptosis approximately 30% to 40% of breast cancer cells population. Compared with the control cells, cucurbitacin B treated cells exhibited obvious aggregation of α-tubulin. The changes were observed within 15 min during incubation with cucurbitacin B^[3]. In the nude mice bearing human MDA-MB-231 breast cancer cells, tumor volume was reduced by 55% in the group that received Cucurbitacin B (1.0 mg/kg) for 6 weeks compared with vehicle controls^[4].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02858388	Otitis Media With Effusion	Phase 3	Completed	-	Italy ... more >> San Gennaro Hospital Naples, Italy, 80136 Collapse <<

参考文献

[1] Gupta P, Srivastava SK. Inhibition of Integrin-HER2 signaling by Cucurbitacin B leads to in vitro and in vivo breast tumor growth suppression. Oncotarget. 2014 Apr 15;5(7):1812-28.
[2] Shang Y, Guo XX, et al. Cucurbitacin-B inhibits neuroblastoma cell proliferation through up-regulation of PTEN. Eur Rev Med Pharmacol Sci. 2014;18(21):3297-303.
[3] Duangmano S, Sae-Lim P, Suksamrarn A, Domann FE, Patmasiriwat P. Cucurbitacin B inhibits human breast cancer cell proliferation through disruption of microtubule polymerization and nucleophosmin/B23 translocation. BMC Complement Altern Med. 2012;12:185
[4] Wakimoto N, Yin D, O'Kelly J, et al. Cucurbitacin B has a potent antiproliferative effect on breast cancer cells in vitro and in vivo. Cancer Sci. 2008;99(9):1793-1797

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.7899 mL
- 8.9493 mL
- 17.8986 mL
- 5 mM
- 0.3580 mL
- 1.7899 mL
- 3.5797 mL
- 10 mM
- 0.1790 mL
- 0.8949 mL
- 1.7899 mL

技术信息

CAS号

6199-67-3

储存条件

粉末: Keep in dark place,Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C32H46O8

运输

蓝冰

分子量

558.70

别名

Cuc B;NSC 49451;NSC 144154;葫芦素 B

溶解度

DMSO	100.0 mg/mL (179.0 mM)
Water	Insoluble

动物实验配方

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Cucurbitacin B/葫芦素B Catalog No. CSN10711

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