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CAS No.: 1818-71-9

Crotonoside/巴豆苷 Catalog No. CSN18820

Synonyms: Isoguanosine;2-Hydroxyadenosine;2-Oxoadenosine

Crotonoside is a naturally occurring active isomer of guanosine found in the seeds of Croton tiglium, which could reduce the blood pressure in rabbits and cats. Crotonoside inhibits FLT3 and HDAC3/6, exhibits selective inhibition in acute myeloid leukemia (AML) cells. Crotonoside could be a promising new lead compound for the treatment of AML.

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技术信息

生物活性

描述Crotonoside is isolated from Chinese medicinal herb, Croton and inhibits FLT3 and HDAC3/6, exhibits selective inhibition in acute myeloid leukemia (AML) cells. In vivo, crotonoside treatment at 70 and 35 mg/kg/d produced significant AML tumor inhibition rates of 93.5% and 73.6%, respectively. Crotonoside (0 - 200 μM) selectively inhibits the viability of AML cell line MV4-11, MOLM-13 (with FLT3-ITD mutant) and KG-1 (without FLT3-ITD mutant) in a dose-dependent manner with an IC50 of 11.6 μM, 12.7 μM and 17.2 μM, respectively. Crotonoside (0 – 100 μM; 7 hours) inhibits the phosphorylation of FLT3. Erk1/2, Akt/mTOR and STAT5 is strongly inhibited by crotonoside at higher concentration of 12.5 μM in a concentration-dependent manner. Crotonoside (0 - 100 μM; 12 hours) exhibits a dose-dependent increase in the percentage of G0/G1 phase and a dose-dependent decrease in the percentage of G2/M and S phases cells^[3].
参考文献

[1] Yan P, Zhang L, et al. Pharmacokinetics and tissue distribution of crotonoside. Xenobiotica. 2017 Jan 19:1-9.
[2] Kim JH, Lee SJ, et al. Isolation of isoguanosine from Croton tiglium and its antitumor activity. Arch Pharm Res. 1994 Apr;17(2):115-8.
[3] Li YZ, Yu S, Yan PA, et al. Crotonoside exhibits selective post-inhibition effect in AML cells via inhibition of FLT3 and HDAC3/6. Oncotarget. 2017;8(61):103087-103099. Published 2017 Sep 8

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.5306 mL
- 17.6528 mL
- 35.3057 mL
- 5 mM
- 0.7061 mL
- 3.5306 mL
- 7.0611 mL
- 10 mM
- 0.3531 mL
- 1.7653 mL
- 3.5306 mL

技术信息

CAS号

1818-71-9

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C10H13N5O5

运输

蓝冰

分子量

283.24

别名

Isoguanosine;2-Hydroxyadenosine;2-Oxoadenosine;2-Oxo-Ado;Isoguanine riboside;NSC 12161;巴豆苷

溶解度

DMSO	57.0 mg/mL (201.2 mM)

动物实验配方

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Crotonoside/巴豆苷 Catalog No. CSN18820

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