|(2E,4E,6E,8E,10E,12E,14E)-1-((((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(((2R,3R,4S ,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)甲基)四氢-2H-吡喃-2-基)16-((2S,3R ,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)2,6,11,15-四甲基十六烷基-2,4,6,8,10 ,12,14-庚二烯酸酯|CsnPharm

CAS No.: 55750-84-0

Crocin II/西红花苷Ⅱ Catalog No. CSN19905

Synonyms: Crocin B;Crocetin gentiobiosylglucosyl ester;Tricrocin

Crocin, a natural product with anti-inflammatory, antihyperlipidemic, antidepressant and anti-apoptotic effects, can ameliorate CCl4-induced liver injury via inhibition of inflammatory cytokines, caspase3 and oxidative stress along with modulation of liver metabolizing enzymes favoring elimination of CCl4 toxic metabolite, it's isolated and purified from the stigma of Crocus sativus L..

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Crocin II is isolated from the fruit of Gardenia jasminoides with antioxidant, anticancer, and antidepressant activity. Crocin II inhibits NO production with an IC50 value of 31.1 μM. Crocin II suppresses the expressions of protein and m-RNA of iNOS and COX-2^[2]. Crocin (40 mg/kg) exhibited the most efficient therapeutic function on CIA (collagen-induced arthritis)rats: the histological scores of joint inflammation, bone erosion, chondrocyte death, cartilage surface erosion, and bone erosion of CIA rats receiving 40 mg/kg crocin treatment were comparable to the normal rats. Moreover, crocin could also inhibit the expression of TNF-α, IL-17, IL-6 and CXCL8 in serum and ankle tissues of CIA rats^[3]. Crocin protected the rat IVDs (intervertebral disc) from the LPS-induced depletion of the ECM (extracellular matrix) components, including proteoglycan and collagen-II. Crocin effectively suppressed the degeneration-related inflammation and catabolism in rat IVDs in vitro and ex vivo^[4]. Crocin treatment significantly alleviated the paw swelling of RA (rheumatoid arthritis) rats. Besides, crocin administration significantly reduced the iNOS production and the serum content of TNF-α, IL-1β, and IL-6. Crocin may exert potent anti-RA effects through inhibiting cytokine^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03022253	Patent Ductus Arteriosus	Phase 3	Completed	-	India ... more >> Post Graduate Institute of Medical Education and Research Chandigarh, India, 160012 Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.2273 mL
- 6.1363 mL
- 12.2726 mL
- 5 mM
- 0.2455 mL
- 1.2273 mL
- 2.4545 mL
- 10 mM
- 0.1227 mL
- 0.6136 mL
- 1.2273 mL

技术信息

CAS号	55750-84-0	储存条件	粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C38H54O19	运输	蓝冰
分子量	814.82	别名	Crocin B;Crocetin gentiobiosylglucosyl ester;Tricrocin;西红花苷II

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Crocin II/西红花苷Ⅱ Catalog No. CSN19905

靶点选择性

请登录您的专属账户

确认信息