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CAS No.: 61438-64-0

Closantel sodium/氯氰碘柳胺钠 Catalog No. CSN10683

Synonyms: KM-0510;KM 051;CS-3976

Closantel Sodium is a salicylanilide anthelmintic compound and exhibits different anthelmintic spectra and apparent toxicity in mammals.

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技术信息

生物活性

描述Closantel (Sodium) is a broad-spectrum salicylanilide antiparasitic drug for a variety of types of animals. Closantel have antiangiogenic activity in zebrafish with a half-inhibitory concentration (IC50) at 1.69 μM on the intersegmental vessels and 1.45 μM on the subintestinal vessels. Closantel also markedly suppressed cancer growth in zebrafish xenotransplanted with human lymphoma, cervical cancer, pancreatic cancer, and liver cancer cells, generally in a dose-dependent manner^[3]. Adult as well as immature Teladorsagia spp. were resistant to albendazole and fenbendazole, immature Teladorsagia spp. to albendazole/closantel, adult and immature Nematodirus spp. to albendazole/closantel and adult Nematodirus spp. to fenbendazole^[4]. At slaughter, 10 days later, all the anthelmintics had resulted in reduced worm burdens in animals infected with the susceptible strain (albendazole 99.0%, levamisole 99.5%, closantel, Inj. and oral ivermectin 100%). By contrast, in the lambs infected with the suspected resistant strain, closantel was 100% effective^[5]. Moreover, the rotational use of closantel as a preferred choice over the benzimidazole group of anthelmintics and/or herbal extracts to meet the acute challenge of in situ development of drug-resistant gastrointestinal nematodes, especially Haemonchus contortus^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.4576 mL
- 7.2880 mL
- 14.5759 mL
- 5 mM
- 0.2915 mL
- 1.4576 mL
- 2.9152 mL
- 10 mM
- 0.1458 mL
- 0.7288 mL
- 1.4576 mL

技术信息

CAS号

61438-64-0

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C22H14Cl2I2N2NaO2

运输

蓝冰

分子量

686.06

别名

KM-0510;KM 051;CS-3976;KS-1256;氯氰碘柳胺钠

溶解度

DMSO	99.0 mg/mL (144.3 mM)
Water	Insoluble
Ethanol	100.0 mg/mL (145.8 mM)

动物实验配方

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Closantel sodium/氯氰碘柳胺钠 Catalog No. CSN10683

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