生物活性

• 描述Clindamycin hydrochloride belongs to the antibiotic family of lincomycin. It has the same antibacterial spectrum as lincomycin, but the antibacterial activity is four to eight times stronger than that of lincomycin^[3]. Clindamycin is an effective antibiotic in the treatment of infections caused by certain gram-positive and gram-negative anaerobic microorganisms. Clindamycin hydrochloride is physically and chemically stable in SuspendIt for 182 days in the refrigerator and at room temperature^[4]. Total clearance (CL) of clindamycin was low, after both IV and oral administration (0.503+/-0.095 vs. 0.458+/-0.087 L/h/kg). Serum clindamycin concentrations following administration of capsules remained above the MICs of very susceptible microorganisms (0.04-0.5 microg/mL) for 12 or 10 h, respectively^[5]. The clindamycin regimen, after USRP (ultrasonic scaling, root planing, and polishing), had a significant effect on plaque and pocket depth measures of periodontal disease but not on gingivitis^[6].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT00398658	Endophthalmitis ... more >> Prophylaxy of Post Traumatic Endophthalmitis Bacterial Endophthalmitis Collapse <<	Phase 4	Completed	-	Iran, Islamic Republic of ... more >> Ophthalmic Research Center Tehran, Iran, Islamic Republic of, 16666 Collapse <<
  NCT01728363	Systemic Infection	Phase 1	Completed	-	United States, Florida ... more >> University of FL Gainesville, Florida, United States, 32610 UFL Health and Baptist Jacksonville, Florida, United States, 32209 United States, Georgia Emory University Atlanta, Georgia, United States, 30322 United States, Indiana Indiana University Indianapolis, Indiana, United States, 46202 United States, Kansas Wesley Medical Wichita, Kansas, United States, 67214 United States, Kentucky University of Louisville Louisville, Kentucky, United States, 40202 United States, Massachusetts Tufts Medical Center Boston, Massachusetts, United States, 02111 United States, New York Kings County Hospital Center Brooklyn, New York, United States, 11203 United States, North Carolina Duke University Durham, North Carolina, United States, 27705 United States, Texas University of Texas Children's Hospital Galveston, Texas, United States, 77555 Collapse <<
  NCT01945450	Endometritis	Not Applicable	Unknown	-	Israel ... more >> Hadassah Medical Organization Not yet recruiting Jerusalem, Israel Collapse <<

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• 参考文献

• [1] Batzias GC, Delis GA, Athanasiou LV. Clindamycin bioavailability and pharmacokinetics following oral administration of clindamycin hydrochloride capsules in dogs. Vet J. 2005 Nov;170(3):339-45.

  [2] Warrick JM, Inskeep GA, et al. Effect of clindamycin hydrochloride on oral malodor, plaque, calculus, and gingivitis in dogs with periodontitis. Vet Ther. 2000 Winter;1(1):5-16.

  [3] Sun Q, Li Y, Qin L. Isolation and identification of two unknown impurities from the raw material of clindamycin hydrochloride. J Sep Sci. 2014;37(19):2682–2687

  [4] Pramar YV, Graves RA, Ledet GA, Phan KV, Bostanian LA, Mandal TK. Stability of Clindamycin Hydrochloride in PCCA Base SuspendIt. Int J Pharm Compd. 2016;20(5):421–425

  [5] Batzias GC, Delis GA, Athanasiou LV. Clindamycin bioavailability and pharmacokinetics following oral administration of clindamycin hydrochloride capsules in dogs. Vet J. 2005;170(3):339–345

  [6] Nielsen D, Walser C, Kodan G, et al. Effects of treatment with clindamycin hydrochloride on progression of canine periodontal disease after ultrasonic scaling. Vet Ther. 2000;1(3):150–158

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