生物活性

• 描述VX-222 is a potent and selective inhibitor of HCV polymerase with IC50 of 0.94-1.2 μM, 15.3-fold less effective for mutant M423T, and 108-fold less effective for mutant I482L.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT00958152	Hepatitis C	Phase 1	Completed	-	New Zealand ... more >> Christchurch, New Zealand Collapse <<
  NCT00911963	Hepatitis C	Phase 1 Phase 2	Completed	-	United States, Georgia ... more >> Gastrointestinal Specialists of Georgia PC Marietta, Georgia, United States, 30060 United States, Michigan Henry Ford Health Sytem Detroit, Michigan, United States, 48202 United States, Texas The liver institute at Methodist hospital Dallas, Texas, United States, 75203 Alamo Medical Research San Antonio, Texas, United States, 78215 Argentina ACLIRES Argentina SRL Buenos Aires, Argentina Hospital Universitario Austral Buenos Aires, Argentina Canada, British Columbia Downtown ID Clinic/University of British Columbia Vancouver, British Columbia, Canada, V6Z 2C7 Canada, Manitoba John Buhler Research Centre Winnipeg, Manitoba, Canada, R3E 3P4 Canada, Ontario Ottawa Hospital Ottawa, Ontario, Canada, K1H 8L6 Puerto Rico Fundacion de Investigation de Diego Santurce, Puerto Rico Collapse <<
  NCT01581138	Chronic Hepatitis C Virus	Phase 2	Completed	-	United States, Alabama ... more >> Birmingham, Alabama, United States United States, California Anaheim, California, United States Riverside, California, United States San Diego, California, United States United States, Colorado Englewood, Colorado, United States United States, Florida Orlando, Florida, United States United States, Georgia Marietta, Georgia, United States United States, Maryland Baltimore, Maryland, United States United States, New York New York, New York, United States United States, North Carolina Asheville, North Carolina, United States Winston-Salem, North Carolina, United States United States, Ohio Cincinatti, Ohio, United States United States, Pennsylvania Pittsburgh, Pennsylvania, United States United States, Tennessee Germantown, Tennessee, United States Nashville, Tennessee, United States United States, Texas Austin, Texas, United States San Antonio, Texas, United States United States, Virginia Norfolk, Virginia, United States Collapse <<

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• 参考文献

• [1] Yi G, Deval J, et al. Biochemical study of the comparative inhibition of hepatitis C virus RNA polymerase by VX-222 and filibuvir. Antimicrob Agents Chemother. 2012 Feb;56(2):830-7.

  [2] Godzik P, Komorowski M, et al. [Inhibitors of hepatitis C virus--current standards and status of investigations] . Przegl Epidemiol. 2010;64(4):473-8.