CAS No.: 470-37-1
Cinobufagine/华蟾蜍精 Catalog No. CSN19441
Synonyms: Cinobufagine;14,15β-Epoxy-3β,16β-dihydroxy-5β,20(22)-bufadienolide 16-acetate;华蟾蜍精
Cinobufagin, a natural product isolated and purified from the glandular body of Bufo bufo gargarizans Cantor, inhibits the proliferation and induces apoptosis, may be related to the mitochondria-mediated pathway and GSK-3β/NF-κB pathway, can significantly relieve cancer pain in mice and raised their pain threshold, mainly upregulating the expression levels of β -END and μ -OR in the hind paw tumor and adjacent tissue, and act as a potent anticancer agent against MM and possibly exerts its effects through the ROS-mediated activation of ERK, JNK and p38 MAPK leading to the activation of caspase-3 in U266 cells.
| 规格 | 价格 | 促销价格 | 库存 | 数量 |
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400-920-2911
sales@csnpharm.cn
tech@csnpharm.cn靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT01236690 Hepatoma Cino... more >>bufacin Injection Collapse << Phase 2 Unknown November 2013 China, Shanghai ... more >> Department of TCM, Changhai Hospital of Shanghai Recruiting Shanghai, Shanghai, China, 200433 Contact: changquan Ling, Doctor +86 21 81873539 qiaocuixia@126.com Collapse << NCT00837239 Pancreatic Cancer Phase 2 Completed - China ... more >> Cancer Hospital Fudan University Shanghai, China Collapse << NCT02530398 Digestive System Cancer ... more >> Malignant Ascites Collapse << Phase 1 Recruiting June 2018 China, Beijing ... more >> Oncology dept; Dongfang Hospital Affiliated to Beijing University of Chinese Medicine Recruiting Beijing, Beijing, China, 100078 Contact: Quanwang Li, master 86-010-67689787 quanwangli@126.com Contact: Jinglin Ye, master 86-15210828680 284504641@qq.com Collapse << - 更多
- 参考文献
- [1] Baek SH, Kim C, et al. Cinobufagin exerts anti-proliferative and pro-apoptotic effects through the modulation ROS-mediated MAPKs signaling pathway. Immunopharmacol Immunotoxicol. 2015 Jun;37(3):265-73.
- [2] Wang ZJ, Sun L, Heinbockel T. Resibufogenin and cinobufagin activate central neurons through an ouabain-like action. PLoS One. 2014 Nov 24;9(11):e113272.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 470-37-1 | 储存条件 |
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| 分子式 | C26H34O6 | 运输 | 蓝冰 | |
| 分子量 | 442.54 | 别名 | Cinobufagine;14,15β-Epoxy-3β,16β-dihydroxy-5β,20(22)-bufadienolide 16-acetate;华蟾蜍精 |
