|1-(吡咯烷-1-基甲酰甲基)-4-(3,4,5-三甲氧基苯丙烯酰基)哌嗪马来酸盐|CsnPharm

CAS No.: 26328-04-1

Cinepazide Maleate/马来酸桂哌齐特 Catalog No. CSN10646

Synonyms: MD-67350;Cinepazide;NSC 291562

Cinepazide Maleate is a maleate salt form of cinepazide which is a vasodilator.

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生物活性

描述Cinepazide Maleate (CM) is a vasodilator. Among various concentrations, 10 μM CM exhibited most significant protection on PC12 cells against OGD (oxygen-glucose deprivation) injury. CM was found to suppress OGD-induced oxidative stress, as supported by its capability of reducing intracellular reactive oxygen species and malondialdehyde production and enhancing superoxide dismutase activity. CM can protect neuronal cells against OGD injury by preserving mitochondrial functions^[2]. T2D (type 2 diabetes) exacerbated CCH-induced (chronic cerebral hypoperfusion) brain damage and cognitive impairment, and CM (cinepazide maleate) ameliorated these effects^[1]. Cinepazide (3 - 30 mg/kg, i.v.) produced a dose-related and transient increase in vertebral, carotid, renal and femoral arterial flow as well as cardiac output and a decrease in total peripheral resistance in anesthetized dogs. Cinepazide resembled cinnarizine and papaverine in that the drug antagonized rabbit aortic contraction induced by KCl, norepinephrine or CaCl2^[3]. Cinepazide in concentrations ranging from 10(-6) to 10(-5) M augmented the relaxing responses to ATP, adenosine and cAMP. Cinepazide slightly reduced the 3H-efflux evoked by electrical stimulation. However, the relaxing response was mostly augmented by the treatment with cinepazide^[4]. Cinepazide maleate combined with edaravone can effectively increase the survival rate of brain cells and promote the volatilization of neurological function in the treatment of hemorrhage in the subretinal space of the omentum^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01831011	Acute Ischemic Stroke	Phase 2	Completed	-	China, Shanxi ... more >> the Department of Neurology Xi an, Shanxi, China, 710032 Collapse <<
NCT01851759	Ischemic Stroke	Phase 2	Unknown	August 2014	China, Shaanxi ... more >> Xijing Hospital Not yet recruiting Xi'an, Shaanxi, China, 710032 Contact: Gang Zhao 02984775361 zhaogang@fmmu.edu.cn Collapse <<
NCT01946919	-	-	Unknown	June 2014	-

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.8742 mL
- 9.3708 mL
- 18.7417 mL
- 5 mM
- 0.3748 mL
- 1.8742 mL
- 3.7483 mL
- 10 mM
- 0.1874 mL
- 0.9371 mL
- 1.8742 mL

技术信息

CAS号

26328-04-1

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C26H35N3O9

运输

蓝冰

分子量

533.57

别名

MD-67350;Cinepazide;NSC 291562;Brendil;Vasodistal;马来酸桂哌齐特

溶解度

DMSO	380.0 mg/mL (712.2 mM) warming
Water	150.0 mg/mL (281.1 mM)

动物实验配方

0.5% CMC-Na

80 mg/mL

clear

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