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CAS No.: 301356-95-6

CID5721353 Catalog No. CSN20561

Synonyms: BCL6 Inhibitor;79-6

CID5721353 is a B-Cell Lymphoma 6 inhibitor (BCL6 inhibitor).

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技术信息

生物活性

描述BCL6, a member of the BTB/POZ family of transcription factors, is the most frequently involved oncogene in diffuse large B cell lymphomas (DLBCLs) ^[2]. CID5721353 is an inhibitor of BCL6 with an IC₅₀ value of 212 μM, which corresponds to a K_i of 147 μM PMID: 20385364. CID5721353 specifically disrupts BCL6 corepressor recruitment and can specifically reactivate BCL6 target genes in BCL6-dependent DLBCLs. It can also Selectively Kill BCL6-Dependent DLBCL Cells ^[2]. CID5721353 Suppresses Human DLBCL Xenografts in Mice. The levels of serum human β₂-microglobulin (a surrogate marker of the xenograft burden) are significantly reduced by CID5721353 in the xenografted mice as compared with their respective controls for the OCI-Ly7 and SU-DHL6 xenografts (p=0.0117 and p=0.0004, respectively) ^[2].
作用机制CID5721353 binds to a Pocket in the Lateral Groove of the BCL6^BTB Domain ^[2].
参考文献

[1] US20120014979
[2] Cerchietti LC. A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo. Cancer Cell. 2010 Apr 13;17(4):400-11.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.1869 mL
- 10.9343 mL
- 21.8686 mL
- 5 mM
- 0.4374 mL
- 2.1869 mL
- 4.3737 mL
- 10 mM
- 0.2187 mL
- 1.0934 mL
- 2.1869 mL

技术信息

CAS号

301356-95-6

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H9BrN2O6S2

运输

蓝冰

分子量

457.28

别名

BCL6 Inhibitor;79-6

溶解度

DMSO	91.0 mg/mL (199.0 mM)
Water	Insoluble
Ethanol	Insoluble

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