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CAS No.: 119-84-6

二氢香豆素 Catalog No. CSN10815

Synonyms: Hydrocoumarin;Chroman-2-one;DHC

Dihydrocoumarin, a natural product isolated and purified from the leaves of Southern sweet-grass., is widespread used as a flavoring agent in beverages, gelatins, puddings, candy, and other food items. It is also as a fragrance in perfumes, creams, and cosmetics.

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技术信息

生物活性

描述Dihydrocoumarin (DHC) is an inhibitor of the Sirtuin family of NAD+-dependent deacetylases^[3]. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively. The microtubule SIRT2 deacetylase is also inhibited with a similar dose dependency (IC50 of 295 μM). Dihydrocoumarin (1-5 mM) increases cytotoxicity in the TK6 cell line in a dose-dependent manner following a 24-h exposure. Dihydrocoumarin (1-5 mM) increases apoptosis in a dose-dependent manner in the TK6 cell line at the 6-h time point. Dihydrocoumarin (1-5 mM) increases p53 lysine 373 and 382 acetylation in a dose-dependent manner in the TK6 cell line following a 24-h exposure period^[4]. Dihydrocoumarin disrupted heterochromatic silencing and inhibited yeast Sir2p as well as human SIRT1 deacetylase activity. DHC exposure in the human TK6 lymphoblastoid cell line also caused concentration-dependent increases in p53 acetylation and cytotoxicity^[4].
参考文献

[1] Haser K, Wenk HH, Schwab W. Biocatalytic production of dihydrocoumarin from coumarin by Saccharomyces cerevisiae. J Agric Food Chem. 2006 Aug 23;54(17):6236-40.
[2] Olaharski AJ, Rine J, et al. The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylases. PLoS Genet. 2005 Dec;1(6):e77.
[3] Jacobi JL, Yang B, Li X, Menze AK, Laurentz SM, Janle EM, Ferruzzi MG, McCabe GP, Chapple C, Kirchmaier AL. Impacts on Sirtuin Function and Bioavailability of the Dietary Bioactive Compound Dihydrocoumarin. PLoS One. 2016 Feb 16;11(2):e0149207
[4] Olaharski AJ, Rine J, Marshall BL, Babiarz J, Zhang L, Verdin E, Smith MT. The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylases. PLoS Genet. 2005 Dec;1(6):e77

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 6.7495 mL
- 33.7476 mL
- 67.4952 mL
- 5 mM
- 1.3499 mL
- 6.7495 mL
- 13.4990 mL
- 10 mM
- 0.6750 mL
- 3.3748 mL
- 6.7495 mL

技术信息

CAS号

119-84-6

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C9H8O2

运输

蓝冰

分子量

148.16

别名

Hydrocoumarin;Chroman-2-one;DHC;二氢香豆素

溶解度

DMSO	95.0 mg/mL (641.2 mM) warming

动物实验配方

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