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CAS No.: 80-77-3

Chlormezanone/氯美扎酮 Catalog No. CSN11041

Synonyms: (±)-Chlormezanone;NSC 169108;Chlormethazanone

Chlormezanone can bind to central benzodiazepine receptors, used in the management of anxiety and in the treatment of muscle spasm.

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技术信息

生物活性

描述Chlormezanone is a centrally acting muscle relaxant introduced in human therapy as a racemic substance. At 1.0 mg/ml, a decrease of proliferative activity was seen after 48 h incubation time of about 50% for the enantiomers and of about 80% for the racemate (PicoGreen) and 50% (enantiomers) or 21% (racemate) in the ATP assay, respectively. ROS production was significantly inhibited at concentrations < or =0.01 mg/ ml by the racemate and the (+)-enantiomer, whereas the (-)-enantiomer was less effective^[3]. Chlormezanone could prove a useful alternative to current therapy for treatment sleeplessness in rheumatic patients^[4]. Chlormezanone binds to oxidized cytochrome P450 in rat liver microsomes with a binding curve according to type I like hexobarbital but less pronounced and with a general shift to the left^[5]. Chlorphenesin (50 mg/kg i.v., 100 mg/kg i.d.) induced a drowsy pattern of spontaneous EEG (Electroencephalographic) consisting of high voltage slow waves in the cortex and amygdala, and desynchronization of hippocampal theta waves^[6]
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02582736	-	-	Completed	-	Canada, Ontario ... more >> Women's College Hospital, Women's College Research Institute Toronto, Ontario, Canada, M5G 1N8 Collapse <<
NCT01450865	Axonal Change, Neuronal ... more >> Pain Collapse <<	Phase 1	Completed	-	Germany ... more >> Multidisciplinary Pain Unit Department of Anaesthesiology University of Munich Pettenkoferstr. 8a Munich, Bavaria, Germany, 80336 Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.6532 mL
- 18.2658 mL
- 36.5316 mL
- 5 mM
- 0.7306 mL
- 3.6532 mL
- 7.3063 mL
- 10 mM
- 0.3653 mL
- 1.8266 mL
- 3.6532 mL

技术信息

CAS号

80-77-3

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C11H12ClNO3S

运输

蓝冰

分子量

273.74

别名

(±)-Chlormezanone;NSC 169108;Chlormethazanone;Trancopal;Chlormethazone;Clormetazanone;Clorilax;Clormetazon;Miorilax;氯美扎酮

溶解度

DMSO	98.0 mg/mL (358.0 mM)
Water	Insoluble

动物实验配方

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Chlormezanone/氯美扎酮 Catalog No. CSN11041

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