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CAS No.: 60925-61-3

Ceforanide/头孢氨酯 Catalog No. CSN21553

Synonyms: Precef;Ceforanido;Ceforanidum

Ceforanide is a semi-synthetic and second-generation cephalosporin antibiotic.

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技术信息

生物活性

描述Ceforanide is a 'second generation' cephalosporin administered intravenously or intramuscularly. It is similar to cefamandole and cefonicid in its in vitro superiority to 'first generation' cephalosporins against several species of Enterobacteriaceae as well as its activity against Haemophilus influenzae, including beta-lactamase-producing strains. Its activity against Staphylococcus aureus is less than that of cefamandole, cefuroxime and first generation cephalosporins. The in vitro activity against Neisseria gonorrhoeae is excellent. Pseudomonas, Acinetobacter and Serratia species, and Bacteroides fragilis are resistant, as are many strains of Proteus and Providencia species^[1]. Clinical trials indicate that ceforanide is effective in the treatment of skin and soft tissue, pulmonary and urinary tract infections, bone and joint infections, and endocarditis. Ceforanide also has been shown to be as effective as cephalothin or cephaloridine when given prophylactically for vaginal hysterectomy^[2]. Ceforanide (30 mg/kg) administered every 12 h, cefazolin (20 mg/kg) administered every 8 h and methicillin or nafcillin (40 mg/kg) administered every 6 h were equally effective in reducing the number of Staphylococcus aureus in vegetations in rabbits with endocarditis. Ceforanide produced higher peak concentrations and greater bactericidal activity in serum than the other drugs and had the longest half-life (5.8 h, compared with 0.4 to 0.8 h for the other agents^[3].
参考文献

[1] Campoli-Richards DM, Lackner TE, Monk JP. Ceforanide. A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy. Drugs. 1987;34(4):411‐437
[2] Barriere SL, Mills J. Ceforanide: antibacterial activity, pharmacology, and clinical efficacy. Pharmacotherapy. 1982;2(6):322‐327
[3] Carrizosa J, Kobasa WD, Kaye D. Comparison of ceforanide, cefazolin, methicillin, and nafcillin in Staphylococcus aureus endocarditis therapy in rabbits. Antimicrob Agents Chemother. 1980;18(4):562‐565

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.9247 mL
- 9.6236 mL
- 19.2473 mL
- 5 mM
- 0.3849 mL
- 1.9247 mL
- 3.8495 mL
- 10 mM
- 0.1925 mL
- 0.9624 mL
- 1.9247 mL

技术信息

CAS号

60925-61-3

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H21N7O6S2

运输

蓝冰

分子量

519.55

别名

Precef;Ceforanido;Ceforanidum;BL-S 786;BL-S786R;ceforanide;monosodium salt;头孢呋尼

溶解度

DMSO	15.5 mg/mL (29.8 mM)
Water	insoluble

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