|(6R,7R)-(新戊酰氧基)甲基 7-((Z)-2-(2-氨基噻唑-4-基)-2-(甲氧基亚氨基)乙酰胺基)-3-甲基-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛烷-2-烯-2-羧酸酯盐酸盐|CsnPharm

CAS No.: 111696-23-2

Cefetamet pivoxil HCl/盐酸头孢他美酯 Catalog No. CSN17472

Synonyms: Ro 15-8075;盐酸头孢他美酯;头孢他美酯盐酸盐

Cefetamet Pivoxil HCl is a third-generation cephalosporin with activity against the major respiratory pathogens.

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技术信息

生物活性

描述Cefetamet pivoxil (Hydrochloride) is an oral third-generation cephalosporin which is hydrolysed to form the active agent, cefetamet. Cefetamet has excellent in vitro activity against the major respiratory pathogens Streptococcus pneumoniae, Haemophilus influenzae, Moraxella (Branhamella) catarrhalis and group A beta-haemolytic streptococci; it is active against beta-lactamase-producing strains of H. influenzae and M. catarrhalis, but has poor activity against penicillin-resistant S. pneumoniae^[3]. Moreover, cefetamet pivoxil showed good activity in experimental infections in the mouse and rat, suggesting satisfactory bioavailability in these animals after oral administration^[4]. The standard dose of cefetamet pivoxil (500 mg twice daily in adults, 10 mg/kg twice daily in children) was well tolerated and proved to be at least as effective as the comparator drugs which were given 3-times a day^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.8247 mL
- 9.1235 mL
- 18.2471 mL
- 5 mM
- 0.3649 mL
- 1.8247 mL
- 3.6494 mL
- 10 mM
- 0.1825 mL
- 0.9124 mL
- 1.8247 mL

技术信息

CAS号

111696-23-2

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H26ClN5O7S2

运输

蓝冰

分子量

548.03

别名

Ro 15-8075;盐酸头孢他美酯;头孢他美酯盐酸盐

溶解度

DMSO	99.0 mg/mL (180.6 mM)
Water	Insoluble
Ethanol	100.0 mg/mL (182.5 mM)

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