生物活性

• 描述CB-1158 is a potent arginase inhibitor. CB-1158 has the potential for anti-tumor activity in renal cell cancer, breast cancer, non-small cell lung cancer, acute myeloid leukemia, and other tumor types where arginase-secreting MDSCs are known to play an immunosuppressive role.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT03314935	Biliary Tract Cancer (BTC) ... more >> Colorectal Cancer (CRC) Endometrial Cancer Gastroesophageal Cancer (GC) Ovarian Cancer Solid Tumors Collapse <<	Phase 1 Phase 2	Recruiting	May 27, 2020	United States, Alabama ... more >> University of Alabama Not yet recruiting Birmingham, Alabama, United States, 35294-3300 USA Mitchell Cancer Center Recruiting Mobile, Alabama, United States, 36604 United States, California UC Davis - Comprehensive Cancer Centre Not yet recruiting Sacramento, California, United States, 95817 United States, Georgia Northwest Georgia Oncology Centers Recruiting Marietta, Georgia, United States, 30060 United States, Texas The University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 START San Antonio Recruiting San Antonio, Texas, United States, 78229 Belgium Grand Hopital de Charleroi - Department of Medical Oncology Not yet recruiting Brussels, Belgium, 6000 Institut Jules Bordet - Clinical Trials Conduct Unit Recruiting Brussels, Belgium, B-1000 United Kingdom University of Liverpool Not yet recruiting Liverpool, United Kingdom, L69 3BX UCL Cancer Institute Recruiting London, United Kingdom, WC1E 6BT The Christie NHS Foundation Trust Recruiting Manchester, United Kingdom, M20 4BX Collapse <<
  NCT03361228	Solid Tumors	Phase 1 Phase 2	Active, not recruiting	January 31, 2019	United States, Alabama ... more >> University of Alabama Birmingham, Alabama, United States, 35294-3300 United States, Illinois The University of Chicago Medicine Chicago, Illinois, United States, 60637 Collapse <<
  NCT02903914	Metastatic Cancer ... more >> Solid Tumors Colorectal Cancer (CRC) Gastric Cancer Head and Neck Cancer Lung Cancer Renal Cell Carcinoma (RCC) Bladder Cancer UC (Urothelial Cancer) Mesothelioma Collapse <<	Phase 1 Phase 2	Recruiting	January 2020	United States, Alabama ... more >> University of South Alabama Recruiting Mobile, Alabama, United States, 36604 United States, Arizona Honor Health/Pinnacle Oncology Hematology Recruiting Scottsdale, Arizona, United States, 85258 Contact: Stephanie Althoff          Principal Investigator: Frank Tsai, MD          University of Arizona Recruiting Tucson, Arizona, United States, 85719 United States, District of Columbia Georgetown Recruiting Washington, District of Columbia, United States, 20007 United States, Maryland Johns Hopkins Recruiting Baltimore, Maryland, United States, 21287 United States, Massachusetts BIDMC Not yet recruiting Boston, Massachusetts, United States, 02215 DFCI Not yet recruiting Boston, Massachusetts, United States, 02215 United States, Michigan Henry Ford Recruiting Detroit, Michigan, United States, 48202 United States, Tennessee Sarah Cannon Research Institute at Tennessee Oncology Recruiting Nashville, Tennessee, United States, 37203 Contact: Erin Fisher          Principal Investigator: Todd Bauer, MD          Vanderbilt Recruiting Nashville, Tennessee, United States, 37232 United States, Texas MD Anderson Recruiting Houston, Texas, United States, 77230-1402 Contact: Yan Zhang, MD, PhD          Principal Investigator: Aung Naing, MD          MD Anderson Recruiting Houston, Texas, United States, 77230 START Recruiting San Antonio, Texas, United States, 78229 Contact: Edwin Blanco-Cepeda, RN Collapse <<

• 参考文献

• [1] Melissa Works, Mark Bennett, et al.Abstract 552: Immuno-oncology agent CB-1158 is a potent and selective arginase inhibitor and causes an immune-mediated anti-tumor response. Cancer Res July 15 2016 (76) (14 Supplement) 552; DOI: 10.1158/1538-7445.AM2016-552

  [2] Matthew Gross, Jason Chen, et al.Abstract A195: CB-1158 inhibits the immuno-oncology target arginase and causes an immune mediated anti-tumor response. Mol Cancer Ther December 1 2015 (14) (12 Supplement 2) A195.