|Atrial Natriuretic Peptide (ANP) (1-28), human, porcine 乙酸盐|CsnPharm

CAS No.: 1366000-58-9

Carperitide acetate Catalog No. CSN23856

Synonyms: Atrial Natriuretic Peptide (ANP) (1-28), human, porcine acetate;Atrial Natriuretic Peptide (ANP) (1-28);human

Atrial Natriuretic Peptide (1-28), human, porcine Acetate is a 28-amino acid hormone, it is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. It inhibits endothelin-1 secretion in a dose-dependent way.

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技术信息

生物活性

描述Atrial natriuretic peptide (ANP) is a diuretic, vasodilatory peptide hormone originally isolated from mammalian hearts. ANP (1-28), human, porcine Acetate is secreted by the human heart. Human ANP (1-28) at 10^-8M and 10^-6M inhibited endothelin-1 secretion by porcine aorta after stimulation with Angiotensin II^[1]. Human ANP (1-28) at a concentration between 10^-10M and 10^-6M inhibited endothelin-1 secretion from cultured human umbilical-vein endothelial cells (HUVECs) in a concentration-dependent manner. Also in HUVECs, treatment with human ANP (1-28) increased the levels of cyclic guanosine 5'-monophosphate^[2]. Human ANP (1-28) bound to a single population of high affinity receptors with a mean equilibrium dissociation constant of 0.46nM in glomeruli from normal rats^[3].
参考文献

[1] Kohno M, Yokokawa K, Horio T, Yasunari K, Murakawa K, Takeda T. Atrial and brain natriuretic peptides inhibit the endothelin-1 secretory response to angiotensin II in porcine aorta. Circ Res. 1992;70(2):241-247
[2] Kohno M, Yasunari K, Yokokawa K, Murakawa K, Horio T, Takeda T. Inhibition by atrial and brain natriuretic peptides of endothelin-1 secretion after stimulation with angiotensin II and thrombin of cultured human endothelial cells. J Clin Invest. 1991;87(6):1999-2004
[3] Ballermann BJ, Hoover RL, Karnovsky MJ, Brenner BM. Physiologic regulation of atrial natriuretic peptide receptors in rat renal glomeruli. J Clin Invest. 1985;76(6):2049-2056

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 0.3184 mL
- 1.5921 mL
- 3.1842 mL
- 5 mM
- 0.0637 mL
- 0.3184 mL
- 0.6368 mL
- 10 mM
- 0.0318 mL
- 0.1592 mL
- 0.3184 mL

技术信息

CAS号	1366000-58-9	储存条件	粉末 Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C129H207N45O41S3	运输	蓝冰
分子量	3140.50	别名	Atrial Natriuretic Peptide (ANP) (1-28), human, porcine acetate;Atrial Natriuretic Peptide (ANP) (1-28);human;porcine acetate

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Carperitide acetate Catalog No. CSN23856

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