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CAS No.: 20575-57-9

Calycosin/毛蕊异黄酮 Catalog No. CSN12352

Synonyms: Cyclosin;异黄酮;毛蕊异黄酮

Calycosin, a phytoestrogen, is a partial agonist of ER and a calcium channel blocker. It also shows prevention of reperfusion injury. Calycosin can be isolated and purified from the herb of Astragalus membranaceus Bge. var. mongholicus with anti-oxidative activity.

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生物活性

描述Calycosin, a phytoestrogen, is a partial agonist of ER and a calcium channel blocker. It also shows prevention of reperfusion injury. Calycosin can be isolated and purified from the herb of Astragalus membranaceus Bge. var. mongholicus with anti-oxidative activity. Calycosin had obvious anti-proliferation effects on SKOV3 cells in a dose- and time-dependent manner. calycosin up-regulated the Bax/Bcl-2 ratio and cleaved caspase-3, cleaved caspase-9 expression in a dose-dependent manner^[3]. In mice bearing MCF-7 or SKBR3 xenografts, tumor growth was inhibited by calycosin, and changes in expression the levels of WDR7-7 and GPR30 (G-protein coupled estrogen receptor 30) in tumor tissues were similar to those in cultured MCF-7 and SKBR3 cells^[4]. Calycosin is more effective in inhibiting breast cancer growth in comparison with genistein, through its regulation of Akt signaling pathways and HOTAIR expression^[5]. Calycosin inhibited oxidative stress and autophagy in CKD (chronic kidney disease) induced skeletal muscle atrophy and in TNF-α-induced C2C12 myotube atrophy, partially by regulating the AMPK/SKP2/CARM1 signalling pathway^[6]. Calycosin dose-dependently inhibited cell viability and increased LDH release in CC (cervical cancer) cells, suggesting the cytotoxic effect of calycosin on CC cells. Calycosin enhanced the apoptotic rate and caspase-3 activity and decreased the number of invaded cells in CC cells. Calycosin inhibited viability, induced apoptosis, and suppressed invasion of CC cells by upregulating tumor suppressor miR-375^[7].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.5179 mL
- 17.5893 mL
- 35.1786 mL
- 5 mM
- 0.7036 mL
- 3.5179 mL
- 7.0357 mL
- 10 mM
- 0.3518 mL
- 1.7589 mL
- 3.5179 mL

技术信息

CAS号

20575-57-9

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H12O5

运输

蓝冰

分子量

284.26

别名

Cyclosin;异黄酮;毛蕊异黄酮

溶解度

DMSO	56.0 mg/mL (197.0 mM)
Water	Insoluble
Ethanol	Insoluble

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