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CAS No.: 64872-77-1

Butoconazole nitrate/硝酸布康唑 Catalog No. CSN17109

Synonyms: RS 35887;Butoconazole (nitrate);(±)-Butoconazole

Butoconazole nitrate is an anti-fungal agent and the IC50s of IL-2, TNFα, IFN and GM-CSF are 7.2 μg/mL, 14.4 μg/mL, 7.36 μg/mL and 7.6 μg/mL, respectively.

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 TNFα

IC50:14.4μg/mL IL-2

IC50:7.2μg/mL IFN

IC50:7.36μg/mL GM-CSF

IC50:7.6μg/mL
描述Butoconazole nitrate (BN) a new imidazole, has been singled out for clinical studies since, in experimental vaginal candidiasis, it proved more effective than either miconazole nitrate (MN) or clotrimazole^[3]. Butoconazole 1-BSR is an effective and safe alternative to longer-term therapy with miconazole nitrate (seven days) for vulvovaginal candidiasis^[4]. The efficacy and safety of the three-day butoconazole treatment regimen were equivalent to those of the seven-day miconazole treatment regimen^[5]. The microbiologic and clinical cure rates achieved with a 3-day course of butoconazole 2% cream have been comparable with those obtained with a 6-day course of miconazole nitrate 2% cream or a 3-day course of clotrimazole vaginal tablets (200 mg/day)^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00694928	Vaginal Infection	Phase 3	Completed	-	-
NCT01039584	Vulvovaginal Candidiasis	Not Applicable	Completed	-	United States, North Carolina ... more >> PharmaNet, Inc. (PharmaNet) Charlotte, North Carolina, United States, 28262 Collapse <<
NCT01039584	-	-	Completed	-	-

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.1062 mL
- 10.5310 mL
- 21.0620 mL
- 5 mM
- 0.4212 mL
- 2.1062 mL
- 4.2124 mL
- 10 mM
- 0.2106 mL
- 1.0531 mL
- 2.1062 mL

技术信息

CAS号

64872-77-1

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C19H18Cl3N3O3S

运输

蓝冰

分子量

474.79

别名

RS 35887;Butoconazole (nitrate);(±)-Butoconazole;Butoconazole;Gynazole-1;Mycelex-3;Butoconazole Nitrate;硝酸布康唑

溶解度

DMSO	95.0 mg/mL (200.1 mM)
Water	Insoluble
Ethanol	Insoluble

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靶点	Description	IC50
TNFα		IC50:14.4μg/mL
IL-2		IC50:7.2μg/mL
IFN		IC50:7.36μg/mL
GM-CSF		IC50:7.6μg/mL

Butoconazole nitrate/硝酸布康唑 Catalog No. CSN17109

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