|5,7-二溴-8-羟基喹啉|CsnPharm

CAS No.: 521-74-4

Broxyquinoline/5,7-二溴-8-羟基喹啉 Catalog No. CSN12725

Synonyms: Dibromohydroxyquinoline;5,7-Dibromo-8-hydroxyquinoline;NSC-1810

Broxyquinoline is an antiprotozoal agent and able to release oxygen free radicals from the water in mucous membranes.

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技术信息

生物活性

描述Broxyquinoline is an antiprotozoal agent. Cryptosporidium parvum causes an opportunistic infection in AIDS patients. This parasite possesses a single fatty acyl-CoA binding protein (CpACBP1) that is localized to the unique parasitophorous vacuole membrane (PVM). Broxyquinoline could inhibit CpACBP1 activity with sub-micromolar IC50 values. Broxyquinoline displayed efficacies against parasite growth in vitro with low micromolar IC50 values of 64.9 μM^[2]. Moreover, broxyquinoline and brobenzoxaldine (and probably other halogenated hydroxyquinolines as well) are safe and effective in therapeutic doses; neurotoxicity is unlikely to occur when these drugs are used according to therapeutic recommendations^[3]. Broxyquinoline was effective against monilial and trichomonal vaginitis^[4].
参考文献

[1] Kim SY, Lee MJ, et al. Effects of clioquinol analogues on the hypoxia-inducible factor pathway and intracelullar mobilization of metal ions. Biol Pharm Bull. 2012;35(12):2160-9.
[2] Fritzler JM, Zhu G. Novel anti-Cryptosporidium activity of known drugs identified by high-throughput screening against parasite fatty acyl-CoA binding protein (ACBP). J Antimicrob Chemother. 2012;67(3):609‐617
[3] Swain R, Bapna JS, Das AK, et al. A study on the neurotoxicity of broxyquinoline and brobenzoxaldine combination in therapeutic doses. Hum Toxicol. 1986;5(1):35‐41
[4] Lövgren T, Salmela I. In vitro sensitivity of Trichomonas vaginalis and Candida albicans to chemotherapeutic agents. Acta Pathol Microbiol Scand B. 1978;86B(3):155‐158

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.3009 mL
- 16.5044 mL
- 33.0087 mL
- 5 mM
- 0.6602 mL
- 3.3009 mL
- 6.6017 mL
- 10 mM
- 0.3301 mL
- 1.6504 mL
- 3.3009 mL

技术信息

CAS号

521-74-4

储存条件

粉末: Keep in dark place,Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C9H5Br2NO

运输

蓝冰

分子量

302.95

别名

Dibromohydroxyquinoline;5,7-Dibromo-8-hydroxyquinoline;NSC-1810;Dibromoxyquinoline;UCB-5055;Paramibe;Brodiar;溴喹啉

溶解度

DMSO	17.0 mg/mL (56.1 mM)
Water	Insoluble
Ethanol	Insoluble

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Broxyquinoline/5,7-二溴-8-羟基喹啉 Catalog No. CSN12725

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