CAS No.: 156161-89-6
BQ-788 sodium salt Catalog No. CSN17348
Synonyms: BQ-788 (sodium salt);BQ-788 Sodium Salt;BQ-788
BQ-788 sodium salt is a potent, selective ETB receptor antagonist with IC50 of 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells, poorly inhibiting the binding to ETA receptors in human neuroblastoma cell line SK-N-MC cells with IC50 of 1300 nM.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT03679780 Cardiovascular Diseases ... more >> Cardiovascular Risk Factor Vasoconstriction Collapse << Phase 1 Not yet recruiting October 1, 2019 United States, Texas ... more >> Engineering Research Building Not yet recruiting Arlington, Texas, United States, 76019 Contact: R. Matthew Brothers, PhD 8172723156 matthew.brothers@uta.edu Contact: John D Akins, MS 8172721835 john.akins@uta.edu Collapse << NCT01395329 Prehypertension ... more >> Hypertension Collapse << Phase 4 Completed - United States, Colorado ... more >> UC-Boulder Clinical and Translational Research Center Boulder, Colorado, United States, 80309 Collapse << NCT01395329 - - Completed - - - 参考文献
- [1] Okada M, Nishikibe M. BQ-788, a selective endothelin ET(B) receptor antagonist. Cardiovasc Drug Rev. 2002 Winter;20(1):53-66.
- [2] Sargent CA, Brazdil R, et al. Effect of endothelin antagonists with or without BQ 788 on ET-1 responses in pithed rats. J Cardiovasc Pharmacol. 1995;26 Suppl 3:S216-8.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 156161-89-6 | 储存条件 |
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| 分子式 | C34H50N5NaO7 | 运输 | 蓝冰 | |
| 分子量 | 663.78 | 别名 | BQ-788 (sodium salt);BQ-788 Sodium Salt;BQ-788 |
