|(+)-(1R,2S,4R)-1,7,7-三甲基双环[2.2.1]庚烷-2-醇|CsnPharm

CAS No.: 464-43-7

Borneol Catalog No. CSN16845

Synonyms: D-Borneol;(1R)-(+)-Borneol;(+)-endo-Borneol

(+)-Borneol is an optical isomer of Borneol. Borneol is a component of some aromatic plant essential oils.

规格	价格	促销价格	库存	数量

400-920-2911

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述(+)-Borneol, a bicyclic monoterpene found in many plants, has many biological activities. In vitro studies, (+)-borneol could improve cell cytotoxicity induced by β-amyloid in human neuroblastoma cells through decreasing reactive oxygen species generation and increasing B-cell lymphoma 2 (Bcl-2) expression. Besides this, it was found that (+)-borneol could depress p-glycoprotein on brain microvascular endothelial cells via medicating the NF-κB pathway. In vivo studies, (+)-borneol could contribute to the improvement of fear and anxiety in rats possibly by modulation of the GABAergic neurotransmission. In addition, (+)-borneol has the ability of strengthening the efficacy of edaravone against DSS-induced colitis in rats.
动物研究
剂量
Mice: 125 mg/kg - 500 mg/kg^[5] (p.o.); 15 μg - 60 μg^[5] (i.t.); 200 mg/kg - 600 mg/kg^[6] (i.g.)

给药途径
p.o., i.t., i.g.
临床研究
NCT号适应症或疾病临床期招募状态预计完成时间地点
NCT01929096 Acute Ischemic Stroke Phase 2 Completed - -
NCT02430350 Acute Ischemic Stroke Phase 3 Completed - -
参考文献

动物研究
剂量	Mice: 125 mg/kg - 500 mg/kg^[5] (p.o.); 15 μg - 60 μg^[5] (i.t.); 200 mg/kg - 600 mg/kg^[6] (i.g.)
给药途径	p.o., i.t., i.g.

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01929096	Acute Ischemic Stroke	Phase 2	Completed	-	-
NCT02430350	Acute Ischemic Stroke	Phase 3	Completed	-	-

[1] Cao B, Ni HY, et al. (+)-Borneol suppresses conditioned fear recall and anxiety-like behaviors in mice. Biochem Biophys Res Commun. 2018;495(2):1588-1593.
[2] Hur J, Pak SC, et al. Borneol alleviates oxidative stress via upregulation of Nrf2 and Bcl-2 in SH-SY5Y cells. Pharm Biol. 2013;51(1):30-5.
[3] Fan X, Chai L, et al. Borneol Depresses P-Glycoprotein Function by a NF-κB Signaling Mediated Mechanism in a Blood Brain Barrier in Vitro Model. Int J Mol Sci. 2015;16(11):27576-88.
[4] Zhang X, Xu F, et al. (+)-Borneol improves the efficacy of edaravone against DSS-induced colitis by promoting M2 macrophages polarization via JAK2-STAT3 signaling pathway. Int Immunopharmacol. 2017.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 6.4830 mL
- 32.4149 mL
- 64.8298 mL
- 5 mM
- 1.2966 mL
- 6.4830 mL
- 12.9660 mL
- 10 mM
- 0.6483 mL
- 3.2415 mL
- 6.4830 mL

技术信息

CAS号

464-43-7

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C10H18O

运输

蓝冰

分子量

154.25

别名

D-Borneol;(1R)-(+)-Borneol;(+)-endo-Borneol;右旋龙脑

溶解度

DMSO	30.0 mg/mL (194.5 mM)

动物实验配方

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