CAS No.: 729607-74-3
BMS-707035 Catalog No. CSN18409
Synonyms: BMS-707035
BMS-707035 is a potent, specific, reversible HIV-I integrase inhibitor with IC50 value of 15 nM.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00397566 HIV Infections Phase 2 Withdrawn - - - 参考文献
- [1] Langley DR, Samanta HK, et al. The terminal (catalytic) adenosine of the HIV LTR controls the kinetics of binding and dissociation of HIV integrase strand transfer inhibitors. Biochemistry. 2008 Dec 23;47(51):13481-8.
- [2] Dicker IB, Samanta HK, et al. Changes to the HIV long terminal repeat and to HIV integrase differentially impact HIV integrase assembly, activity, and the binding of strand transfer inhibitors. J Biol Chem. 2007 Oct 26;282(43):31186-96.
- [3] Cotelle P. 3-Hydroxy-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-ones as new HIV-1 integrase inhibitors WO2011046873 A1. Expert Opin Ther Pat. 2011;21(11):1799‐1804
- [4] Al-Mawsawi LQ, Al-Safi RI, Neamati N. Anti-infectives: clinical progress of HIV-1 integrase inhibitors. Expert Opin Emerg Drugs. 2008;13(2):213‐225
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 729607-74-3 | 储存条件 |
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| 分子式 | C17H19FN4O5S | 运输 | 蓝冰 | |||||
| 分子量 | 410.42 | 别名 | BMS-707035 | |||||
| 溶解度 |
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动物实验配方 |
