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CAS No.: 202821-81-6

BMS-191011 Catalog No. CSN26269

Synonyms: BMS-A;UNII-LW7MXS978N

BMS-191011 (BMS-A) is an opener of the large-conductance, Ca2+-activated potassium (maxi-K) channel, effective in stroke models. It has also shown neuroprotective properties in two distinct animal models of stroke- MCAO in the SHR rat and a normotensive model of focal stroke.

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400-920-2911

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生物活性

描述Potassium (K+) channels participate in many physiological processes, cardiac function, cell proliferation, neuronal signaling, muscle contractility, immune function, hormone secretion, osmotic pressure, changes in gene expression, and are involved in critical biological functions, and in a variety of diseases^[1]. BMS-191011 (BMS-A) is an opener of the large-conductance, Ca2+-activated potassium (maxi-K) channel, effective in stroke models^[2]. BMS-191011 (10-100 µg/kg, i.v.) and NS 1619 (0.1-1.0 µg/kg, i.v.) increased the diameter of retinal arterioles without altering systemic blood pressure and heart rate significantly. The vasodilator responses to BMS-191011 were significantly diminished by intravitreal injection of iberiotoxin (an inhibitor of BK(Ca) channels, 20 pmol/eye)^[3]. A 29-day treatment with L-citrulline, significantly ameliorated the impaired acetylcholine- and BMS-191011-induced retinal vasodilation in diabetic rats without affecting their plasma glucose levels^[4]. BMS 191011 caused fetal coronary artery relaxation and BKCa current activation that was unaffected by maternal nutrient restriction^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.6975 mL
- 13.4876 mL
- 26.9752 mL
- 5 mM
- 0.5395 mL
- 2.6975 mL
- 5.3950 mL
- 10 mM
- 0.2698 mL
- 1.3488 mL
- 2.6975 mL

技术信息

CAS号	202821-81-6	储存条件	粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C16H10ClF3N2O3	运输	蓝冰
分子量	370.71	别名	BMS-A;UNII-LW7MXS978N

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