|6-溴靛玉红-3'-丙酮肟|CsnPharm

CAS No.: 667463-85-6

BIO-acetoxime/6-溴靛玉红-3'-丙酮肟 Catalog No. CSN16227

Synonyms: BIA;GSK-3 Inhibitor X;(2′Z,3′E)-6-Bromoindirubin-3′-acetoxime

BIO-acetoxime is an inhibitor of GSK3α and GSK3β with IC50 of 10 nM.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述In mammals, different genes encode two closely related glycogen synthase kinase-3 (GSK-3) enzymes, GSK-3α and GSK-3β which function in Wnt signal-transducing pathways, insulin action, apoptosis and circadian rhythm. BIO-acetoxime is a potent and selective GSK-3 inhibitor, with IC₅₀s of 10 nM for both GSK-3α and GSK-3β. It also shows weak effect on CDK5/p35, CDK2/cyclin A, and CDK1/cyclin B with IC₅₀s of 2.4, 4.3 and 63 μM, respectively^[3]. Treatment of OC3 cells with BIO-acetoxime (5 or 10 μM) prevented HSV-1-induced cell death. In addition, BIO-acetoxime alleviated HSV-1-induced apoptosis. In oral epithelial cells, BIO-acetoxime inhibited HSV-1 propagation in a dose-dependent manner^[4]. In a rat limbic seizure model, the pilocarpine-induced seizures are indeed significantly attenuated after i.p. injection of 0.5 mg/kg BIO-acetoxime^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.5112 mL
- 12.5562 mL
- 25.1124 mL
- 5 mM
- 0.5022 mL
- 2.5112 mL
- 5.0225 mL
- 10 mM
- 0.2511 mL
- 1.2556 mL
- 2.5112 mL

技术信息

CAS号

667463-85-6

储存条件

粉末: Keep in dark place,Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H12BrN3O3

运输

蓝冰

分子量

398.21

别名

BIA;GSK-3 Inhibitor X;(2′Z,3′E)-6-Bromoindirubin-3′-acetoxime;6-Bromoindirubin acetoxime;6-Bromoindirubin-3′-acetoxime

溶解度

DMSO	108.0 mg/mL (271.2 mM)
Water	insoluble

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

BIO-acetoxime/6-溴靛玉红-3'-丙酮肟 Catalog No. CSN16227

靶点选择性

请登录您的专属账户

确认信息