CAS No.: 1392429-79-6
BI-882370 Catalog No. CSN24795
BI-882370 is a potent and selective RAF kinase inhibitor that binds to the ATP binding site of the kinase positioned in the DFG-out (inactive) conformation of the BRAF kinase. BI-882370 (BI 882370) inhibits the oncogenic BRAFV600E-mutant, the WT BRAF and CRAF kinases with IC50s of 0.4, 0.8, and 0.6 nM, respectively. BI-882370 also inhibits SRC family kinases[1].
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技术信息
| CAS号 | 1392429-79-6 | 储存条件 |
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| 分子式 | C28H33F2N7O2S | 运输 | 蓝冰 | |
| 分子量 | 569.67 | 别名 |
