|2-(氨甲酰氧基)-N,N,N-三甲基1-丙铵氯化物|CsnPharm

CAS No.: 590-63-6

Bethanechol chloride/氯贝胆碱 Catalog No. CSN10441

Synonyms: Carbamyl-β-methylcholine chloride;Bethanechol (chloride);(±)-Bethanechol

Bethanechol chloride is a selective mAchR receptor agonist as a parasympathomimetic choline carbamate.

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技术信息

生物活性

描述Bethanechol Chloride (BeCh) is a selective muscarinic receptor agonist without any effect on nicotinic receptors. BeCh was tested from 0.01 to 3000 μM for its ability to inhibit peak current of untreated and PTX-treated cells, IC50 were 8.2μM and 21μM, respectively^[3]. A more pronounced inhibition of cancer induction occurred in the group treated daily with Bethanechol Chloride after BOP (N-nitrosobis(2-oxopropyl)amine)^[4]. Bethanechol Chloride was used to treat salivary gland dysfunction induced by head and neck radiotherapy, improvement in XT (xerostomia) symptoms, and some changes in saliva composition were shownCotomacio C, Campos L, Simões A, Jaguar G, Crosato EM, Abreu-Alves F. Influence of bethanechol on salivary parameters in irradiated patients. Med Oral Patol Oral Cir Bucal. 2017 Jan 1;22(1):e76-e83. https://pubmed.ncbi.nlm.nih.gov/27918737/.
参考文献

[1] Carter WJ. Unexpected benefits of bethanechol in adults with cerebral palsy. Med J Aust. 2008 Sep 1;189(5):293.
[2] Agrawal A, Hila A, et al. Bethanechol improves smooth muscle function in patients with severe ineffective esophageal motility. J Clin Gastroenterol. 2007 Apr;41(4):366-70.
[3] Liu L, Rittenhouse AR. Pharmacological discrimination between muscarinic receptor signal transduction cascades with bethanechol chloride. Br J Pharmacol. 2003 Apr;138(7):1259-70.
[4] Pour PM, Donnelly T, Stepan K. Modification of pancreatic carcinogenesis in the hamster model. 7. Inhibitory effect of bethanechol chloride. Am J Pathol. 1983 Aug;112(2):178-84.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.0844 mL
- 25.4220 mL
- 50.8440 mL
- 5 mM
- 1.0169 mL
- 5.0844 mL
- 10.1688 mL
- 10 mM
- 0.5084 mL
- 2.5422 mL
- 5.0844 mL

技术信息

CAS号

590-63-6

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C7H17ClN2O2

运输

蓝冰

分子量

196.68

别名

Carbamyl-β-methylcholine chloride;Bethanechol (chloride);(±)-Bethanechol;NSC 30783;氯贝胆碱

溶解度

DMSO	20.0 mg/mL (101.7 mM) warming
Water	300.0 mg/mL (1525.4 mM)

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