|beta-七叶素|CsnPharm

CAS No.: 11072-93-8

Synonyms: β-Aescin;β-七叶素

beta-Escin selectively targets the glioblastoma-initiating cell population and reduces cell viability.

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400-920-2911

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描述beta-Escin (β-escin) selectively targets the glioblastoma-initiating cell population and reduces cell viability. β-escin-evoked attenuation of NF-κB-dependent signaling, increase in MMP-14 and decrease in COUP-TFII content and a rise in cholesterol biosynthesis could be beneficial in alleviating muscle-damaging processes. In rat model, β-escin rescues regenerating muscles from atrophy. The drug reduces inflammatory infiltration, increases the number of muscle fibers and decreases fibrosis. β-escin reduces macrophage infiltration into injured muscles and promotes their M2 polarization. It also alters transcription of muscle regeneration-related genes: Myf5, Myh2, Myh3, Myh8, Myod1, Pax3 and Pax7, and Pcna. In C2C12 myoblasts in vitro, β-escin inhibits TNF-α-induced activation of NF-κB, reduces secretion of MMP-9 and increases ALDH activity^[3]. β-escin exerts inhibitory effect on the basic fibroblast growth factor (bFGF)-induced proliferation, migration and tube formation, as well as CAM (chorioallantoic membrane) angiogenesis in vivo. The inhibition of critical steps of angiogenic process observed with β-escin could be partially explained by suppression of Akt activation in response to bFGF^[4]. β-escin sodium has a marked antiproliferative effect on A549 cells at least in part by inhibiting the JAK/STAT signaling pathway, but not by a cytotoxic effect^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03104985	Trophic Ulcers ... more >> Chronic Venous Insufficiency Collapse <<	Not Applicable	Completed	-	Russian Federation ... more >> Tula Municipal Clinical Hospital №2 Tula, Russian Federation, 300002 Collapse <<
NCT03104985	-	-	Completed	-	-
NCT00213928	Lymphedema of Arm	Phase 2	Completed	-	United States, Wisconsin ... more >> University of Wisconsin Madison, Wisconsin, United States, 53792 Collapse <<

实验方案

技术信息

CAS号	11072-93-8	储存条件	粉末 Keep in dark place,Inert atmosphere,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式		运输	蓝冰
分子量	0.00	别名	β-Aescin;β-七叶素

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