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CAS No.: 132-17-2
Synonyms: Benzatropine mesylate;Benzotropine mesylate;Benztropine methanesulfonate
Benztropine mesylate is a central muscarinic antagonist and a DAT inhibitor with IC50 of 118 nM, indicated for symptomatic relief of parkinsonism and drug-induced extrapyramidal reactions.
生物活性
靶点 | DAT IC50:118nM |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|---|---|---|---|---|
NCT01833897 | Bipolar Disorder | Phase 4 | Completed | - | United States, New York ... more >> New York State Psychiatric Institute New York, New York, United States, 10032 Collapse << |
NCT00009672 | Radiculopathy ... more >> Sciatica Collapse << | Phase 2 | Completed | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << |
NCT00167856 | Neuropathic Pain ... more >> Pain Spinal Cord Injuries Collapse << | Not Applicable | Completed | - | United States, Florida ... more >> VA Medical Center, Miami Miami, Florida, United States, 33125 Collapse << |
实验方案
技术信息
CAS号 | 132-17-2 | 储存条件 |
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分子式 | C22H29NO4S | 运输 | 蓝冰 | |||||||||
分子量 | 403.54 | 别名 | Benzatropine mesylate;Benzotropine mesylate;Benztropine methanesulfonate;Benztropine (mesylate);NSC 169913;Benztropine Mesylate;Cogentin;Cogentin mesylate;MLS000737056;NSC42199;ST50997629;甲磺酸苯扎托品 | |||||||||
溶解度 |
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动物实验配方 |
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NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT01833897 | Bipolar Disorder | Phase 4 | Completed | - | United States, New York ... more >> New York State Psychiatric Institute New York, New York, United States, 10032 Collapse << |
NCT00009672 | Radiculopathy ... more >> Sciatica Collapse << | Phase 2 | Completed | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << |
NCT00167856 | Neuropathic Pain ... more >> Pain Spinal Cord Injuries Collapse << | Not Applicable | Completed | - | United States, Florida ... more >> VA Medical Center, Miami Miami, Florida, United States, 33125 Collapse << |
NCT00802100 | Schizophrenia | Phase 4 | Completed | - | United States, California ... more >> SHANTI Clinical Trials Colton, California, United States, 92324 Stanford University Palo Alto, California, United States, 94305 United States, Connecticut Yale University New Haven, Connecticut, United States, 06519 United States, Florida University of Miami School of Medicine Miami, Florida, United States, 33316 United States, Georgia Medical College of Georgia Augusta, Georgia, United States, 30912 United States, Maryland Clinical Insights Glen Burnie, Maryland, United States, 21061 United States, Massachusetts University of Massachusetts Worcester, Massachusetts, United States, 01605 United States, Michigan Wayne State University Detroit, Michigan, United States, 48201 United States, Minnesota University of Minnesota School of Medicine Minneapolis, Minnesota, United States, 55454 United States, New York Research Foundation for Mental Hygiene New York, New York, United States, 10032 United States, North Carolina Duke University Medical Center-John Umstead Hospital Butner, North Carolina, United States, 27509 United States, Texas University of Texas Southwestern Medical Center Dallas, Texas, United States, 75235 Baylor College of Medicine Houston, Texas, United States, 77030 Collapse << |
NCT00802100 | - | - | Completed | - | - |
NCT00964886 | Back Pain | Phase 2 | Completed | - | United States, California ... more >> VA San Diego Healthcare System, San Diego, CA San Diego, California, United States, 92161 Collapse << |
NCT00066937 | Temporomandibular Joint Disord... more >>ers Collapse << | Phase 2 | Completed | - | United States, Maryland ... more >> University of Maryland, Dental School Baltimore, Maryland, United States, 21201 Collapse << |
NCT00066937 | - | - | Completed | - | - |
NCT00457366 | Agitation | Phase 4 | Completed | - | United States, California ... more >> Los Angeles County Hospital Los Angeles, California, United States, 90033 Collapse << |
NCT00715377 | Schizophrenia ... more >> Schizoaffective Disorder Schizophreniform Disorder Delusional Disorder Psychotic Disorders Collapse << | Not Applicable | Terminated(Insufficient subjec... more >>t accrual) Collapse << | - | Canada, Ontario ... more >> Centre for Addiction and Mental Health Toronto, Ontario, Canada, M5T 1R8 Collapse << |
NCT00018200 | Back Pain Sci... more >>atica Collapse << | Phase 2 | Completed | - | United States, California ... more >> VA San Diego Healthcare System, San Diego San Diego, California, United States, 92161 Collapse << |
NCT00964886 | - | - | Completed | - | - |
NCT00000793 | HIV Infections ... more >> Peripheral Nervous System Disease Collapse << | Phase 2 | Completed | - | - |
NCT00000333 | Cocaine-Related Disorders | Phase 2 | Completed | - | United States, District of Col... more >>umbia Washington DC VA Washington, District of Columbia, United States, 20422 Collapse << |
NCT01833897 | - | - | Completed | - | - |
靶点 | Description | IC50 |
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DAT | IC50:118nM |
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