|苯甲酰胺|CsnPharm

CAS No.: 55-21-0

苯甲酰胺 Catalog No. CSN10401

Synonyms: Benzenecarboxamide;Phenylamide;NSC-3114

Benzamide, an inhibitor of poly (ADP-ribose) polymerase, is a derivative of benzoic acid.

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技术信息

生物活性

描述Benzamide (Benzenecarboxamide) is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH)-induced neurotoxicity in vitro. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature. Benzamide (160 mg/kg; IP, 2 injection by a 4 h interval) attenuates the METH-induced dopamine depletions. Benzamide (160 mg/kg; IP, single dosage) has no acute effect on striatal dopamine metabolism and does not reduce body temperature^[3].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01636947	Nausea Vomiti... more >>ng Collapse <<	Phase 4	Completed	-	-
NCT01636947	-	-	Completed	-	-
NCT00080444	Vomiting	Phase 3	Completed	-	-

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参考文献

[1] Wang XY, Lim-Jurado M, et al. Treatment of allergic rhinitis and urticaria: a review of the newest antihistamine drug bilastine. Ther Clin Risk Manag. 2016 Apr 13;12:585-97.
[2] Kun E, Kirsten E, et al. Cell cycle-dependent intervention by benzamide of carcinogen-induced neoplastic transformation and in vitro poly(ADP-tibosyl)ation of nuclear proteins in human fibroblasts. Proc Natl Acad Sci U S A. 1983 Dec;80(23):7219-23.
[3] Cosi C, Chopin P, Marien M. Benzamide, an inhibitor of poly(ADP-ribose) polymerase, attenuates methamphetamine-induced dopamine neurotoxicity in the C57B1/6N mouse. Brain Res. 1996;735(2):343-348.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 8.2551 mL
- 41.2757 mL
- 82.5514 mL
- 5 mM
- 1.6510 mL
- 8.2551 mL
- 16.5103 mL
- 10 mM
- 0.8255 mL
- 4.1276 mL
- 8.2551 mL

技术信息

CAS号

55-21-0

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C7H7NO

运输

蓝冰

分子量

121.14

别名

Benzenecarboxamide;Phenylamide;NSC-3114;苯甲酰胺

溶解度

DMSO	24.0 mg/mL (198.1 mM)
Water	Insoluble
Ethanol	24.0 mg/mL (198.1 mM)

动物实验配方

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NCT01636947	Nausea Vomiti... more >>ng Collapse <<	Phase 4	Completed	-	-
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苯甲酰胺 Catalog No. CSN10401

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