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CAS No.: 91599-74-5

Benidipine HCl/贝尼地平盐酸盐 Catalog No. CSN10397

Synonyms: KW-3049;Benidipine (hydrochloride);(±)-Benidipine

Benidipine HCl is a dihydropyridine calcium channel blocker for the treatment of hypertension.

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描述Benidipine hydrochloride, a calcium channel blocker (CCB), inhibited SFTSV (Severe fever with thrombocytopenia syndrome virus) replication in vitro. Benidipine hydrochloride was revealed to inhibit virus infection through impairing virus internalization and genome replication^[3]. Histopathologically neuroprotective effects of benidipine hydrochloride was seen in the cerebral cortex tissues. Benidipine hydrochloride can play a certain protective role in the cerebral I/R injury. The protective effect of this agent may be related to the improvement on the antioxidant capacity of brain tissue and the inhibition of overproduction of inflammatory cytokines^[4]. Moreover, patients with hypertension have high plasma TBARS (thiobarbituric acid reactive substance), and benidipine hydrochloride decreases not only blood pressure but also oxidative stress in the clinical practice^[5]. Benidipine has a more potent antihypertensive effect than cilnidipine and also a renoprotective effect, indicating the high usefulness of benidipine in hypertensive patients with diabetes^[6]. Combination therapy with benidipine hydrochloride and candesartan cilexetil may contribute to the suppression of arteriosclerosis and may be useful for elderly hypertensive patients with diabetes mellitus^[7].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00135551	Cardiovascular Disease	Phase 4	Completed	-	Japan ... more >> Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine Ube, Yamaguchi, Japan, 755-8505 Collapse <<
NCT02646397	Chronic Kidney Disease	Phase 4	Unknown	December 2017	China, Shanghai ... more >> Department of Nephrology, Shanghai Changzheng Hospital Shanghai, Shanghai, China, 200003 Collapse <<
NCT00135551	Cardiovascular Disease	Phase 4	Completed	-	Japan ... more >> Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine Ube, Yamaguchi, Japan, 755-8505 Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.8450 mL
- 9.2248 mL
- 18.4495 mL
- 5 mM
- 0.3690 mL
- 1.8450 mL
- 3.6899 mL
- 10 mM
- 0.1845 mL
- 0.9225 mL
- 1.8450 mL

技术信息

CAS号

91599-74-5

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C28H32ClN3O6

运输

蓝冰

分子量

542.02

别名

KW-3049;Benidipine (hydrochloride);(±)-Benidipine;Benidipine Hydrochloride;Coniel

溶解度

DMSO	8.0 mg/mL (14.8 mM)
Water	Insoluble
Ethanol	Insoluble

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