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CAS No.: 64-65-3

Bemegride/贝美格 Catalog No. CSN17089

Synonyms: 3-Ethyl-3-methylglutarimide;Bemegrid;Antibarbi

Bemegride can stimulate central nervous system and release barbiturate poisoning.

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技术信息

生物活性

描述Bemegride had an antagonistic action on the GABAA receptor, suppressing both GABA- and pentobarbitone-evoked whole-cell currents to similar extents^[3]. The intensity of withdrawal syndrome in rats treated with barbital alone or in combination with the stimulant bemegride or pentylenettrazol was approximately parallel to the degree of related central nervous system depression^[4]. The bemegride discriminative stimulus generalized to PTZ (20mg/kg) and was antagonized by chlordiazepoxide (10 mg/kg). Bemegride and cocaine generalized to the PTZ (pentylenetetrazol) discriminative stimulus in a dose-dependent manner, but d-amphetamine, methylphenidate, and nicotine did not^[5]. Administration of subconvulsant doses of bemegride results in extensive enhancement of sensory responsiveness to auditory, visual, somatosensory and vibrissa stimulation of neurons in the medullary and mesencephalic reticular formation (RF)^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 6.4435 mL
- 32.2177 mL
- 64.4354 mL
- 5 mM
- 1.2887 mL
- 6.4435 mL
- 12.8871 mL
- 10 mM
- 0.6444 mL
- 3.2218 mL
- 6.4435 mL

技术信息

CAS号

64-65-3

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C8H13NO2

运输

蓝冰

分子量

155.19

别名

3-Ethyl-3-methylglutarimide;Bemegrid;Antibarbi;Agipnon;Ahypnon;Eukraton;Malysol;Mikedimide;Zentraleptin;贝美格;贝美瑞德

溶解度

DMSO	29.0 mg/mL (186.9 mM)
Water	Insoluble
Ethanol	30.0 mg/mL (193.3 mM)

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