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CAS No.: 1357920-84-3

Belizatinib/贝扎替尼（TSR-011） Catalog No. CSN22546

Synonyms: TSR-011

Belizatinib is a selective ALK inhibitor with IC50 value of 0.7nM, as well as shows potency against TRK A, B, and C with IC50 values<3nM.

规格	价格	促销价格	库存	数量

400-920-2911

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tech@csnpharm.cn

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400-920-2911

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技术信息

生物活性

描述Anaplastic lymphoma kinase (ALK), a member of the insulin receptor tyrosine kinase family (RTK), is encoded by the ALK gene on chromosome 2p23^[1]. Belizatinib is a potent, dual ALK and TrkA, TrkB and TrkC inhibitor which has high affinity for wild-type recombinant ALK kinase activity with an IC₅₀ value of 0.7 nM, and exerts sustained potent inhibition of ALK-dependent tumour growth in mouse models. In an ongoing phase I/IIa trial, Belizatinib exerted antitumour activity in at least 2/3 non-small cell lung cancer (NSCLC) ALK+ patients with dysaesthesia who had previously progressed on crizotinib^[1].
参考文献

[1] Sullivan I, Planchard D. ALK inhibitors in non-small cell lung cancer: the latest evidence and developments. Ther Adv Med Oncol. 2016 Jan;8(1):32-47. doi: 10.1177/1758834015617355. PMID: 26753004; PMCID: PMC4699265.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.7309 mL
- 8.6545 mL
- 17.3090 mL
- 5 mM
- 0.3462 mL
- 1.7309 mL
- 3.4618 mL
- 10 mM
- 0.1731 mL
- 0.8655 mL
- 1.7309 mL

技术信息

CAS号

1357920-84-3

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C33H44FN5O3

运输

蓝冰

分子量

577.73

别名

TSR-011

溶解度

DMSO	530.0 mg/mL (917.4 mM)
Water	insoluble

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