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CAS No.: 88899-55-2
Synonyms: BafA1;NSC-381866;巴佛洛霉素A1
Bafilomycin A1 is an inhibitor of vacuolar H+-ATPase with IC50 of 0.44 nM.
生物活性
实验方案
技术信息
CAS号 | 88899-55-2 | 储存条件 |
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分子式 | C35H58O9 | 运输 | 蓝冰 | |||
分子量 | 622.83 | 别名 | BafA1;NSC-381866;巴佛洛霉素A1 | |||
溶解度 |
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动物实验配方 |
Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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human H4 cells | 0.4 μM | Function assay | 24 h | Induction of light chain 3-GFP level in human H4 cells at 0.4 uM after 24 hrs by high throughput fluorescence microscopy relative to control | 18024584 |
human HeLa cells | 400 nM | Function assay | - | Induction of autophagy in human HeLa cells expressing EGFP-LC3 assessed as increase in LC3-2 level at 400 nM | 18391949 |
human MCF7 cells | - | Function assay | 4 h | Inhibition of rapamycin-induced autophagy in human MCF7 cells expressing EGFP-LC3 assessed as decrease in EGFP levels at 100 nM after 4 hrs by Western blotting relative to control | 20028134 |
mouse RAW264.7 cells | 100 nM | Apoptosis assay | 16 h | Induction of apoptosis in mouse RAW264.7 cells assessed as late apoptotic cells at 100 nM after 16 hrs using annexin V-propidium iodide staining by flow cytometry | 19307359 |
RAW 264.7 cells | 100 nM | Function assay | - | Antimicrobial activity against Salmonella enterica Typhimurium 14028 infected in RAW 264.7 cells assessed as increased nitric oxide production in infected cells at 100 nM | 19307359 |
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