|2-(4-氟苯基)-6-甲基-4-(3-(三氟甲基)苯基)-1,2-二氢二吡唑并[3,4-b：3'，4'-d]吡啶-3(6H)-酮|CsnPharm

CAS No.: 635324-72-0

B7/CD28 interaction inhibitor 1 Catalog No. CSN27546

Synonyms: MDK-24720;CTLA-4 inhibitor

B7/CD28 interaction inhibitor 1 is a potent B7.1-CD28 interaction inhibitor with an IC50 of 50 nM.

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400-920-2911

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技术信息

生物活性

描述The interaction of co-stimulatory molecules on T cells with B7 molecules on antigen presenting cells plays an important role in the activation of naive T cells. Agents that disrupt these interactions should have applications in treatment of transplant rejection as well as autoimmune diseases. B7/CD28 interaction inhibitor 1 is a potent small molecule inhibitor of the B7.1-CD28 interaction with an IC₅₀ of 50 nM^[2].
作用机制B7/CD28 interaction inhibitor 1 binds to the V-like domain of human B7.1^[2].
参考文献

[1] Green NJ, et al. Structure-activity studies of a series of dipyrazolo[3,4-b:3',4'-d]pyridin-3-ones binding to the immune regulatory protein B7.1. Bioorg Med Chem. 2003 Jul 3;11(13):2991-3013.
[2] Green NJ, et al. Structure-activity studies of a series of dipyrazolo[3,4-b:3',4'-d]pyridin-3-ones binding to the immune regulatory protein B7.1. Bioorg Med Chem. 2003 Jul 3;11(13):2991-3013

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3400 mL
- 11.6999 mL
- 23.3998 mL
- 5 mM
- 0.4680 mL
- 2.3400 mL
- 4.6800 mL
- 10 mM
- 0.2340 mL
- 1.1700 mL
- 2.3400 mL

技术信息

CAS号

635324-72-0

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H13F4N5O

运输

蓝冰

分子量

427.35

别名

MDK-24720;CTLA-4 inhibitor

溶解度

DMSO	85.0 mg/mL (198.9 mM)

动物实验配方

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