CAS No.: 34539-65-6
β,β-Dimethylacrylalkannin Catalog No. CSN13601
Synonyms: Arnebin 1;b,b-Dimethylacrylalkannin
beta,beta-Dimethylacrylalkannin, a natural product isolated and purified from the roots of Lithospermum erythrorhizon with radical scavenging activity, can be potential therapeutics against tumor cell growth because of its unique DNA damaging abilities additional to enzyme inhibition similar to those of doxorubicin, shows remarkable cytotoxic activity against HT-29, MDA-MB-231 and PC-3 cell lines, comparable or stronger than the other compounds and positive control CPT-11 (CAMPTOSTAR®, irinotecan) with IC50 values in between 0.1uM and 1uM and it has great potential as topo I inhibitors compared to other compounds and CPT-11, with 2-3uM inhibition value, and exhibits inhibitory activities on PTP1B with IC50 values of 0.36±0.08 μMol·L-1.
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| CAS号 | 34539-65-6 | 储存条件 |
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| 分子式 | C21H22O6 | 运输 | 蓝冰 | |
| 分子量 | 370.40 | 别名 | Arnebin 1;b,b-Dimethylacrylalkannin |
