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CAS No.: 27589-33-9

Azosemide/阿佐塞米 Catalog No. CSN27535

Synonyms: PLE 1053;SK-110;阿佐塞米

Azosemide, a sulfonamide loop diuretic, is a potent NKCC1 inhibitor with IC50s of 0.246 µM and 0.197 µM for hNKCC1A and NKCC1B, respectively.

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描述Azosemide, a sulfonamide loop diuretic, was the most potent NKCC1 inhibitor (IC50s 0.246 µM for hNKCC1A and 0.197 µM for NKCC1B), being about 4-times more potent than bumetanide. Azosemide inhibits the sodium-potassium-chloride-cotransporter human variants hNKCC1A and hNKCC1B^[3]. After oral administration of the same dose of azosemide and furosemide, the diuretic effect was similar between the two drugs, but after intravenous administration, the effect of azosemide was 5.5-8 times greater than that in furosemide^[4]. Azosemide was absorbed from all regions of GI tract studied and approximately 93.5, 79.1, 86.1, and 71.5% of the doses (5, 10, 20, and 30 mg/kg, respectively) were absorbed between 1 and 24 hr after oral administration^[5]. Azosemide is a new monosulfamyl diuretic which inhibits solute transport throughout the thick ascending limb of the loop of Henle. Azosemide 40 mg caused less potassium excretion than 40 mg of furosemide but there was no significant difference in the sodium/potassium excretion ratio^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.6966 mL
- 13.4830 mL
- 26.9660 mL
- 5 mM
- 0.5393 mL
- 2.6966 mL
- 5.3932 mL
- 10 mM
- 0.2697 mL
- 1.3483 mL
- 2.6966 mL

技术信息

CAS号

27589-33-9

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C12H11ClN6O2S2

运输

蓝冰

分子量

370.84

别名

PLE 1053;SK-110;阿佐塞米

溶解度

DMSO	240.0 mg/mL (647.2 mM) warming

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