|3-(2-氰基丙烷-2-基)-N-(3-((7-甲氧基-4-基)氨基)-4-甲基苯基)苯甲酰胺|CsnPharm

CAS No.: 942507-42-8

AZ304 Catalog No. CSN22609

AZ304 is an inhibitor of BRAF and can target many kinases. The IC50s for wild type BRAF, V600E mutant BRAF and wild type CRAF are 79 nM, 38 nM and 68 nM, respectively. It can also inhibit p38 (IC50 = 6 nM) and CSF1R (IC50 = 35 nM).

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述AZ304 is a dual BRAF inhibitor, with IC50 values of 38, 79, 68, 6 and 35nM for BRAF^V600E, BRAF, CRAF, p38 and CSF1R, respectively, exerting potent inhibitory effects on both wild type and V600E mutant forms of the serine/threonine-protein kinase BRAF. AZ304 at concentration<1μM effectively inhibited a panel of human cancer cell lines with different BRAF and RAS genetic statuses, by suppressing ERK phosphorylation. The anti-proliferative activity of AZ304 cannot be retained by EGF in CRC cell lines with different BRAF mutation status. Oral gavage with 10mg/kg AZ304, twice daily, for 10 days, exhibited anti-tumour activity in RKO and Caco-2 xenograft model. And combination of Cetuximab with AZ304 could enhance this anti-tumour activity^[2].
动物研究
剂量
Nude Mice: 10 mg/kg^[1] (p.o.)

给药途径
p.o.
参考文献

动物研究
剂量	Nude Mice: 10 mg/kg^[1] (p.o.)
给药途径	p.o.

[1] Ma R, Xu L, et al. AZ304, a novel dual BRAF inhibitor, exerts anti-tumour effects in colorectal cancer independently of BRAF genetic status. Br J Cancer. 2018 May;118(11):1453-1463.
[2] Ma R, Xu L, Qu X, Che X, Zhang Y, Fan Y, Li C, Guo T, Hou K, Hu X, Drew L, Shen M, Cheung T, Liu Y. AZ304, a novel dual BRAF inhibitor, exerts anti-tumour effects in colorectal cancer independently of BRAF genetic status. Br J Cancer. 2018 May;118(11):1453-1463. doi: 10.1038/s41416-018-0086-x. Epub 2018 May 14. PMID: 29755114; PMCID: PMC5988692.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.2147 mL
- 11.0737 mL
- 22.1474 mL
- 5 mM
- 0.4429 mL
- 2.2147 mL
- 4.4295 mL
- 10 mM
- 0.2215 mL
- 1.1074 mL
- 2.2147 mL

技术信息

CAS号

942507-42-8

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C27H25N5O2

运输

蓝冰

分子量

451.52

别名

溶解度

DMSO	90.0 mg/mL (199.3 mM)
Water	Insoluble
Ethanol	5.0 mg/mL (11.1 mM)

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

AZ304 Catalog No. CSN22609

靶点选择性

请登录您的专属账户

确认信息