CAS No.: 329221-38-7
AX20017 Catalog No. CSN19106
Synonyms: PknG Inhibitor
AX20017 is a small-molecule protein kinase G (PknG) inhibitor with an IC50 of 0.39 μM.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Santhi N, Aishwarya S. Insights from the molecular docking of withanolide derivatives to the target protein PknG from Mycobacterium tuberculosis. Bioinformation. 2011;7(1):1-4.
- [2] Walburger A, Koul A, et al. Protein kinase G from pathogenic mycobacteria promotes survival within macrophages. Science. 2004 Jun 18;304(5678):1800-4.
- [3] Walburger A, Koul A, Ferrari G, Nguyen L, Prescianotto-Baschong C, Huygen K, Klebl B, Thompson C, Bacher G, Pieters J. Protein kinase G from pathogenic mycobacteria promotes survival within macrophages. Science. 2004 Jun 18;304(5678):1800-4
- [4] Khan MZ, Nandicoori VK. Deletion of pknG Abates Reactivation of Latent Mycobacterium tuberculosis in Mice. Antimicrob Agents Chemother. 2021 Mar 18;65(4):e02095-20
- [5] Scherr N, Honnappa S, Kunz G, Mueller P, Jayachandran R, Winkler F, Pieters J, Steinmetz MO. Structural basis for the specific inhibition of protein kinase G, a virulence factor of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12151-6
- [6] Santhi N, Aishwarya S. Insights from the molecular docking of withanolide derivatives to the target protein PknG from Mycobacterium tuberculosis. Bioinformation. 2011;7(1):1-4
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 329221-38-7 | 储存条件 |
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| 分子式 | C13H16N2O2S | 运输 | 蓝冰 | |||||
| 分子量 | 264.34 | 别名 | PknG Inhibitor | |||||
| 溶解度 |
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动物实验配方 |
