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CAS No.: 451493-31-5

AV-412 Catalog No. CSN16948

Synonyms: MP412

AV-412 is a potent dual inhibitor of EGFR and ErbB2(IC50=19 nM) tyrosine kinases, including the mutant EGFR(L858R IC50=0.51 nM, T790M IC50=0.79 nM). It inhibits autophosphorylation of EGFR and ErbB2 with IC(50) of 43 and 282 nM.

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描述AV-412 is a potent dual inhibitor of EGFR and ErbB2(IC50=19 nM) tyrosine kinases, including the mutant EGFR(L858R IC50=0.51 nM, T790M IC50=0.79 nM). It inhibits autophosphorylation of EGFR and ErbB2 with IC(50) of 43 and 282 nM.
参考文献

[1] Suzuki T, Fujii A, et al. Ubiquitination and downregulation of ErbB2 and estrogen receptor-alpha by kinase inhibitor MP-412 in human breast cancer cells. J Cell Biochem. 2011 Sep;112(9):2279-86.
[2] Suzuki T, Fujii A, et al. Pharmacological characterization of MP-412 (AV-412), a dual epidermal growth factor receptor and ErbB2 tyrosine kinase inhibitor. Cancer Sci. 2007 Dec;98(12):1977-84.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.1745 mL
- 5.8726 mL
- 11.7453 mL
- 5 mM
- 0.2349 mL
- 1.1745 mL
- 2.3491 mL
- 10 mM
- 0.1175 mL
- 0.5873 mL
- 1.1745 mL

技术信息

CAS号	451493-31-5	储存条件	粉末 Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C41H44ClFN6O7S2	运输	蓝冰
分子量	851.41	别名	MP412

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