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CAS No.: 1049780-58-6

AUTEN-99 HBr Catalog No. CSN20514

Synonyms: Autophagy enhancer-99 hydrobromide;Autophagy Enhancer-99;AUTEN-99

Auten-99 is an inhibitor of the myotubularin phosphatase Jumpy (also called MTMR14), acrossing the blood-brain barrier and exerting potent neuroprotective effects.

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实验方案

技术信息

生物活性

描述AUTEN-99 is a brain permeable autophagy inducer through inhibiting the myotubularin-related phosphatase MTMR14/Jumpy, a negative regulator of autophagic membrane formation. It markedly increases the number of autolysosomal structures at 10μM in HeLa cells, and enhanced levels of LC3B-II protein (the membrane conjugated form of LC3B) in HeLa cells exposure to Bafilomycin A1 (50nM). This suggested that AUTEN-99 elevated autophagic flux rather than merely strengthening the formation of autophagosomes without autolysosomal degradation. Oral administration or intraperitoneal injection with AUTEN-99 increased the number autophagic structures in mice in vivo. Also it induced autophagy in the Drosophila larval fat body, prevented the progression of neurodegenerative symptoms in Drosophila models of Parkinson's disease and impeded the progression of neurodegenerative symptoms in a Drosophila model of Huntington's disease. It exhibited neuroprotective effects on isolated neurons under oxidative stress-induced conditions at 2.5μM^[2].
动物研究
剂量
BALB/C mice: 390μM^[1] (i.p.)

给药途径
i.p.
参考文献

动物研究
剂量	BALB/C mice: 390μM^[1] (i.p.)
给药途径	i.p.

[1] Kovács T, Billes V, et al. The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms. Sci Rep. 2017 Feb 16;7:42014.
[2] Kovács T, Billes V, Komlós M, Hotzi B, Manzéger A, Tarnóci A, Papp D, Szikszai F, Szinyákovics J, Rácz Á, Noszál B, Veszelka S, Walter FR, Deli MA, Hackler L Jr, Alfoldi R, Huzian O, Puskas LG, Liliom H, Tárnok K, Schlett K, Borsy A, Welker E, Kovács AL, Pádár Z, Erdős A, Legradi A, Bjelik A, Gulya K, Gulyás B, Vellai T. The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms. Sci Rep. 2017 Feb 16;7:42014. doi: 10.1038/srep42014. PMID: 28205624; PMCID: PMC5311965.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.7833 mL
- 13.9166 mL
- 27.8332 mL
- 5 mM
- 0.5567 mL
- 2.7833 mL
- 5.5666 mL
- 10 mM
- 0.2783 mL
- 1.3917 mL
- 2.7833 mL

技术信息

CAS号	1049780-58-6	储存条件	粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C17H15BrN2S	运输	蓝冰
分子量	359.28	别名	Autophagy enhancer-99 hydrobromide;Autophagy Enhancer-99;AUTEN-99;Auten-99 hydrochloride. Auten-99 HBr

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