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CAS No.: 173937-91-2
Synonyms: ABT-627;(+)-A 127722;A-147627
Atrasentan is an endothelin receptor antagonist (IC50=0.0551 nM, ETA) being developed for the treatment of prostate cancer.
生物活性
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT00017264 | Brain and Central Nervous Syst... more >>em Tumors Collapse << | Phase 1 | Completed | - | United States, Alabama ... more >> University of Alabama at Birmingham Comprehensive Cancer Center Birmingham, Alabama, United States, 35294-3300 United States, Florida H. Lee Moffitt Cancer Center and Research Institute Tampa, Florida, United States, 33612-9497 United States, Georgia Winship Cancer Institute of Emory University Atlanta, Georgia, United States, 30322 United States, Maryland Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore, Maryland, United States, 21231-2410 United States, Massachusetts Massachusetts General Hospital Cancer Center Boston, Massachusetts, United States, 02114 United States, Michigan Josephine Ford Cancer Center at Henry Ford Hospital Detroit, Michigan, United States, 48202 United States, North Carolina Comprehensive Cancer Center at Wake Forest University Winston-Salem, North Carolina, United States, 27157-1082 United States, Ohio Cleveland Clinic Taussig Cancer Center Cleveland, Ohio, United States, 44195 United States, Pennsylvania Abramson Cancer Center at University of Pennsylvania Medical Center Philadelphia, Pennsylvania, United States, 19104 United States, Texas University of Texas Health Science Center at San Antonio San Antonio, Texas, United States, 78284-7811 Collapse << |
NCT00920764 | Chronic Kidney Disease ... more >> Diabetic Nephropathy Collapse << | Phase 2 | Completed | - | - |
NCT00039429 | Kidney Cancer | Phase 2 | Completed | - | - |
实验方案
技术信息
CAS号 | 173937-91-2 | 储存条件 |
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分子式 | C29H38N2O6 | 运输 | 蓝冰 | |
分子量 | 510.62 | 别名 | ABT-627;(+)-A 127722;A-147627;A 127722;NSC720763;Abbott 147627;US brand name: Xinlay |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT00017264 | Brain and Central Nervous Syst... more >>em Tumors Collapse << | Phase 1 | Completed | - | United States, Alabama ... more >> University of Alabama at Birmingham Comprehensive Cancer Center Birmingham, Alabama, United States, 35294-3300 United States, Florida H. Lee Moffitt Cancer Center and Research Institute Tampa, Florida, United States, 33612-9497 United States, Georgia Winship Cancer Institute of Emory University Atlanta, Georgia, United States, 30322 United States, Maryland Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore, Maryland, United States, 21231-2410 United States, Massachusetts Massachusetts General Hospital Cancer Center Boston, Massachusetts, United States, 02114 United States, Michigan Josephine Ford Cancer Center at Henry Ford Hospital Detroit, Michigan, United States, 48202 United States, North Carolina Comprehensive Cancer Center at Wake Forest University Winston-Salem, North Carolina, United States, 27157-1082 United States, Ohio Cleveland Clinic Taussig Cancer Center Cleveland, Ohio, United States, 44195 United States, Pennsylvania Abramson Cancer Center at University of Pennsylvania Medical Center Philadelphia, Pennsylvania, United States, 19104 United States, Texas University of Texas Health Science Center at San Antonio San Antonio, Texas, United States, 78284-7811 Collapse << |
NCT00920764 | Chronic Kidney Disease ... more >> Diabetic Nephropathy Collapse << | Phase 2 | Completed | - | - |
NCT00039429 | Kidney Cancer | Phase 2 | Completed | - | - |
NCT00036543 | Prostate Cancer | Phase 3 | Completed | - | - |
NCT00271492 | Endothelial Dysfunction | Phase 3 | Completed | - | United States, Minnesota ... more >> Mayo Clinic Rochester, Minnesota, United States, 55905 Collapse << |
NCT00046943 | Prostate Cancer | Phase 3 | Completed | - | United States, California ... more >> Jonsson Comprehensive Cancer Center, UCLA Los Angeles, California, United States, 90095-1738 Collapse << |
NCT00036556 | Prostatic Neoplasms | Phase 3 | Completed | - | - |
NCT00038662 | Prostatic Neoplasms | Phase 2 | Completed | - | - |
NCT00127478 | Prostate Cancer ... more >> Adenocarcinoma Collapse << | Phase 2 Phase 3 | Completed | - | United States, California ... more >> Prostate Oncology Specialists Marina Del Rey, California, United States, 32589 Western Clinical Research, Inc. Torrance, California, United States, 90505 United States, Florida South Florida Medical Research Aventura, Florida, United States, 33180 United States, New York Beth Isreal Medical Center, Phillips Ambulatory Care Ceneter New York, New York, United States, 10003 ViaHealth Rochester General Hospital Center for Urology Rochester, New York, United States, 14609 United States, Oregon Oregon Urology Specialist, Division of Clinical Research Springfield, Oregon, United States, 97477 United States, Pennsylvania University of Pittsburgh Department of Urology Pittsburgh, Pennsylvania, United States, 15232 Canada, Alberta Cross Cancer Institute Edmonton, Alberta, Canada, T6G 1Z2 Canada, British Columbia CroMedia Prime/Prime Trials Vancouver Hospital Vancouver, British Columbia, Canada, V5Z 1M9 Canada, Ontario Ken Janz MD Burlington, Ontario, Canada, 3V2CAN McMaster Institute of Urology Hamilton, Ontario, Canada, L8N 4A6 Canada, Quebec McGill University Health Center Royal VIctoria Hosptial Montreal, Quebec, Canada, H3A1A1 France Hoptial de Ranguell Service d'Urologie Toulouse, Cedex, France, 31043 Netherlands University Hospital Rotterdam, Department of Urology Rotterdam, Netherlands United Kingdom Leighton Hospital Urology Research Dept., Michael Heal Outpatients Dept. Crewe, United Kingdom, CW1 4QT Collapse << |
NCT00653328 | Fallopian Tube Cancer ... more >> Ovarian Cancer Peritoneal Cavity Cancer Collapse << | Phase 2 | Terminated(Abbott (drug manufa... more >>cturer) discontinued manufacture of ABT-627) Collapse << | - | United States, Georgia ... more >> Central Georgia Hematology Oncology Associates, P.C. Macon, Georgia, United States, 31201 United States, Kentucky Kentuckiana Cancer Institute Louisville, Kentucky, United States, 40202 United States, Tennessee The Jones Clinic Germantown, Tennessee, United States, 38138 Jackson-Madison County Hospital Jackson, Tennessee, United States, 383013956 St. Thomas Health Services Nashville, Tennessee, United States, 37205 Vanderbilt-Ingram Cancer Center Nashville, Tennessee, United States, 37232 Collapse << |
NCT00653328 | - | - | Terminated(Abbott (drug manufa... more >>cturer) discontinued manufacture of ABT-627) Collapse << | - | - |
NCT01424319 | Chronic Kidney Disease ... more >> Diabetic Nephropathy Collapse << | Phase 2 | Completed | - | Japan ... more >> Site Reference ID/Investigator# 62022 Azumino, Japan Site Reference ID/Investigator# 58124 Chiba, Japan Site Reference ID/Investigator# 57486 Fujisawa, Japan Site Reference ID/Investigator# 55097 Ibaraki, Japan Site Reference ID/Investigator# 56982 Ina, Japan Site Reference ID/Investigator# 55093 Kawagoe, Japan Site Reference ID/Investigator# 57485 Kawasaki, Japan Site Reference ID/Investigator# 55092 Koriyama, Japan Site Reference ID/Investigator# 56524 Matsumoto, Japan Site Reference ID/Investigator# 57242 Nagano, Japan Site Reference ID/Investigator# 60965 Nagoya-city, Japan Site Reference ID/Investigator# 55781 Nagoya, Japan Site Reference ID/Investigator# 55304 Suwa, Japan Site Reference ID/Investigator# 59474 Tokyo, Japan Site Reference ID/Investigator# 59967 Ueda, Japan Site Reference ID/Investigator# 55095 Yokohama, Japan Site Reference ID/Investigator# 57484 Yokohama, Japan Site Reference ID/Investigator# 59842 Yokohama, Japan Collapse << |
NCT00134056 | Metastatic Cancer ... more >> Prostate Cancer Collapse << | Phase 3 | Completed | - | - |
NCT01356849 | Chronic Kidney Disease ... more >> Diabetic Nephropathy Collapse << | Phase 2 | Completed | - | - |
NCT00134056 | - | - | Completed | - | - |
NCT01399580 | Chronic Kidney Disease ... more >> Diabetic Nephropathy Collapse << | Phase 2 | Completed | - | - |
NCT00181558 | Prostate Cancer ... more >> Adenocarcinoma of the Prostate Collapse << | Phase 2 | Completed | - | United States, Massachusetts ... more >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Collapse << |
NCT02118714 | Nephropathy D... more >>iabetes Collapse << | Phase 2 | Completed | - | United States, California ... more >> Alliance Research Centers /ID# 125945 Laguna Hills, California, United States, 92653-3621 Frank Clark Urology Center /ID# 147794 Santa Monica, California, United States, 90404 United States, Illinois Research by Design, LLC /ID# 160784 Evergreen Park, Illinois, United States, 60805 Southern IL Univ School of Med /ID# 129010 Springfield, Illinois, United States, 62702 United States, Louisiana Crescent City Clinical Res Ctr /ID# 150989 Metairie, Louisiana, United States, 70006 Tulane Univ /ID# 130308 New Orleans, Louisiana, United States, 70112 United States, New York Albany Medical College /ID# 131068 Albany, New York, United States, 12208 United States, Pennsylvania Urologic Consultants of Southeastern Pennsylvania /ID# 124277 Bala-Cynwyd, Pennsylvania, United States, 19004-1017 United States, Virginia Eastern Virginia Med School /ID# 153740 Norfolk, Virginia, United States, 23507-1627 Germany Charite Research Organisation GmbH /ID# 154264 Berlin, Germany, 10117 Italy Ospedale S. Carlo Borromeo /ID# 151672 Milan, Italy, 20153 SCDU Nefrologia e dialisi-CMID /ID# 151673 Torino, Italy, 10154 Spain Hospital Universitario Reina S /ID# 151692 Cordoba, Spain, 14004 Collapse << |
NCT01858532 | Diabetic Nephropathy | Phase 3 | Terminated(Strategic considera... more >>tions) Collapse << | - | - |
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