|(2S,4R)-1-((R)-2-乙酰胺基-3-((6-(2-((S)-4-(4-氯苯基)-2,3,9-三甲基-6H-噻吩并[3,2-f][1,2,4]三唑并[4,3-a][1,4]二氮杂卓-6-基)乙酰胺基)己基)硫基)-3-甲基丁酰基)-4-羟基-N-(4-(4-甲基噻唑-5-基)苄基)吡咯烷-2-甲酰胺|CsnPharm

CAS No.: 2098836-45-2

Synonyms: BRD4 Degrader AT1

AT1 is a highly selective Brd4 degrader with a modified VHL ligand retained binding to VHL (Kd = 330 nM).

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400-920-2911

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400-920-2911

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描述AT1 is a highly selective Brd4 degrader with a modified VHL ligand retained binding to VHL (Kd = 330 nM). Treatment with 1μM or 3μM AT1 for 24h significantly degraded Brd4 in HeLa cells. Compared with the previous Brd4 degrader MZ1, AT1 exhibited much more selectivity as it had no effect on Brd2, 3 protein while MZ1 exerted a broader and more profound effect across all BET proteins at the same concentration^[1].
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CAS号	2098836-45-2	储存条件	粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C48H58ClN9O5S3	运输	蓝冰
分子量	972.68	别名	BRD4 Degrader AT1

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