|(R)-2-(6-(5-氯-2-((四氢-2H-吡喃-4-基)氨基)嘧啶-4-基)-1-氧代异吲哚啉-2-基)-N-((S)-1-(3-氟-5-甲氧基苯基)-2-羟乙基)丙酰胺|CsnPharm

CAS No.: 2095719-92-7

ASTX029 Catalog No. CSN27671

Synonyms: ERK1/2 inhibitor 2

ASTX-029 is selective inhibitor of the extracellular signal-regulated kinases 1 and 2 (ERK 1/2) with potential antineoplastic activity.

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400-920-2911

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实验方案

技术信息

生物活性

描述The Ras/Raf/MAPK (MEK)/ERK pathway is the most important signalling cascade among all MAPK signal transduction pathways, and plays a crucial role in the survival and development of tumour cells. The extracellular signal-regulated kinases ERK1 and ERK2 are evolutionarily conserved, ubiquitous serine-threonine kinases that regulate cellular signalling under both normal and pathological conditions. ASTX029 is a synthetic small molecule inhibitor of extracellular signal-regulated kinases ERK1/2. ASTX-029 inhibits the proliferation and survival of ERK-dependent tumor cells^[1].
参考文献

[1] ERK 1/2 Inhibitor ASTX029

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.7122 mL
- 8.5611 mL
- 17.1222 mL
- 5 mM
- 0.3424 mL
- 1.7122 mL
- 3.4244 mL
- 10 mM
- 0.1712 mL
- 0.8561 mL
- 1.7122 mL

技术信息

CAS号

2095719-92-7

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C29H31ClFN5O5

运输

蓝冰

分子量

584.04

别名

ERK1/2 inhibitor 2

溶解度

DMSO	100.0 mg/mL (171.2 mM)
Water	Insoluble
Ethanol	50.0 mg/mL (85.6 mM)

动物实验配方

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